Human trophoblastic cell surface antigen 2 (Trop2) is a glycoprotein, a cellular marker of trophoblastic and stem cells, and a calcium signaling transducer involved in several signaling pathways, leading to the proliferation, invasion, and metastasis of tumors. It is expressed at a low level in ...
Case discussion: A 70-year-old woman with previously treated BRCA2 mutation-positive fallopian tube cancer is diagnosed with biopsy-proven ER/PR-positive, HER2-positive breast cancer (BC) and liver metastases Share Video Player is loading.Play Video This is a modal window. This video is eithe...
experience more clinically aggressive disease, present with more advanced disease at diagnosis and suffer higher mortality relative to women of other ancestries1,2. While socioeconomic and structural barriers explain some of this disparity, women of African ancestry also experience higher rates of estro...
- in cases where the whole or a high proportion of the mammographic lesion has been removed, a small metal marker clip is deployed at the biopsy site. MR-guided vacuum biopsy is performed on Siemens MR scanners (Impact Expert and Vision) using a dedicated breast biopsy coil and a VB-devic...
Breast cancer is the most common malignant disease worldwide, with over 2.26 million new cases in 2020. Its diagnosis is determined by a histological review of breast biopsy specimens, which can be labor-intensive, subjective, and error-prone. Artificial
Circulating tumor cells for 'real time biopsy' at the time of metastatic disease The development of metastatic disease is assumed to be a highly selective process. Only a small portion of tumor cells of the primary tumor probably have the ability to initiate metastatic growth in different organ ...
Core needle biopsy (CNB) is clinically used to verify the diagnosis of malignancy before surgery in BC patients [39], but there is a risk of enhancing tumor development by this procedure. In a mouse experiment, a needle biopsy significantly increased the frequency of distant metastases, and inf...
Of the 473 HR+HER2− breast cancer biopsy specimens, TILs were evaluated in 382 cases. The tpCR rate was 4.2%. ROC curve analysis suggested that TILs did not show significant predictive value for tpCR (AUC = 0.578, SE = 0.104, 95% CI = 0.375–0.782, P = 0.377,...
For benign patients: acknowledged breast cancer risk factors (childless, lack of breast feeding, breast trauma / inflammations / biopsy, etc.) [30] Frequent co-morbidities (Diabetes type 2, cardiovascular disease, depression) [31, 32] Environmental particularities (geographic factors, environmental to...
[28]. Similarly to our mouse data, this study also shows that some, but not all, patients may have distant metastases seeded by lymph node lesions. In a long-term study of 3329 BC patients that underwent RLN biopsy, Nathanson et al., show that LNMs are predictive of distant metastases,...