The results provide insight into why mutation in just one of the eight BRC repeats would affect the way that BRCA2 protein interacts with the RAD51 filament. Disruption of a single RAD51 interaction site, one of several simultaneous interactions occurring throughout the BRC repeat-containing exon...
1. Miron, S. et al. DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfaces.Nucleic Acids Res.52, 7337–7353 (2024). Author information Authors and Affiliations Department of Biochemistry, University of Cambridge, Cambridge, UK James M. Dunce Wellcome Centre for Cel...
A model fungal system that reproduces the BRCA2-RAD51 interaction offers the opportunity to understand at the molecular level the mechanism of DSS1 activation.doi:10.4161/cc.3.3.700Kojic, MiloradHolloman, William K.Taylor & FrancisCell Cycle...
The interaction between tumor suppressor BRCA2 and DSS1 is essential for RAD51 recruitment and repair of DNA double stand breaks (DSBs) by homologous recombination (HR). We have generated mice with a leucine to proline substitution at position 2431 of BRCA2, which disrupts this interaction. Alt...
Recent work has shown that the murine BRCA2 tumor suppressor protein interacts with the murine RAD51 protein. This interaction suggests that BRCA2 participates in DNA repair. Residues 3196–3232 of the murine BRCA2 protein were shown to be involved in this interaction. Here, we report the ...
RAD51 interacts with the evolutionary conserved BRC motifs in the human breast cancer suscepti... Recent work has shown that the murine BRCA2 tumor suppressor protein interacts with the murine RAD51 protein. This interaction suggests that BRCA2 particip... AKC Wong,R Pero,PA Ormonde,... - ...
BRCA2 protein regulates recombinational repair by interaction with RAD51 via a series of degenerate BRC repeat motifs encoded by exon 11 (BRCA2(996-2113)), and an unrelated C-terminal domain (BRCA2(3265-3330)). BRCA2 is also required for meiotic recombination. Here, we show that human ...
Interaction between ER signaling pathway and BRCA2 Located in 13q12.3, the BRCA2 gene is involved in cell cycle regulation, signal transduction, and DNA damage repair through the Rad51 binding region [14, 15]. The most important function of the BRCA2 protein is participation in damage repair...
The BRCA2 protein is involved in homologous recombination repair via its interaction with RAD51 recombinase, and this function suppresses tumorigenesis. BRCA2 expression levels are important for preventing tumorigenesis, because cells with decreased expression of BRCA2 have heightened sensitivity to agents ...
However, BRCA2ex3 may also be directly involved in the maintenance of chromosomal stability through its interaction with RPA, single-strand DNA (ssDNA)-binding replication protein A, and PALB2, two proteins required for development of the DNA-damage response (DDR), including BRCA2/RAD51-...