However, BRCA1 methylation was more often present in lymph-node-positive patients [122]. According to a meta-analysis, the hypermethylation of BRCA1 in cfDNA, among other markers, was associated with poor prognosis in ER + /PR + BrCa [123]. In a recent work by Yen et al., ...
Additionally, we assessed the correlation between cell fitness and olaparib treatment, as well as the correlation between cisplatin and olaparib responses. b, Schematic showing our filtering strategy to integrate classification scores based on cell fitness and drug response data to accurately categorize ...
D. et al. Disruption of the expected positive correlation between breast tumor size and lymph node status in BRCA1-related breast carcinoma. Cancer 98, 1569–1577 (2003). PubMed Google Scholar Goffin, J. R. et al. Impact of germline BRCA1 mutations and overexpression of p53 on prognosis...
tumors [57]. As mentioned above, BRCA1 and Rad51 are key mediators of HR, and thus their foci formation is present in HR-proficient cells, whereas γH2AX and 53BP1 as conventional DNA damage markers build foci in HR-deficient cells [58]. Interestingly, researchers proved that the positive...
positive or PR-positive. Patients with human epidermal growth factor receptor II (HER2) testing scored as IHC 3+ (positive) or 2+ (equivocal) and with fluorescence in situ hybridization (FISH)-confirmed amplification were considered HER2-positive. All patients received treatment according to ...
ContextAmong cancer-free women aged 35 years or older, tamoxifen reduced the incidence of estrogen receptor (ER)–positive but not ER-negative breast cancer. The effect of tamoxifen on breast cancer incidence among women at extremely high risk due toinheritedBRCA1orBRCA2mutationsis unknown.Objective...
(NCT00494234), 12 patients in the 400 mg olaparib arm had ER-positive disease and treatment responses were observed.57In another study (Study 42), responses to olaparib as late-line therapy were observed in 4 of 32 patients (12.5%) with ER-positive disease and 4 of 30 (13.3%) with ...
Top: correlation matrix of these genes indicating strong positive pairwise correlations within control samples (Pearson’s R = 0.92, 0.91, and 0.89) and modest positive correlations within BRCA2 carriers (Pearson’s R = 0.33, 0.28, 0.27). Sample IDs, age, and parity of the samples are as...
The risk of contralateral breast cancer in patients from BRCA1/2 negative high risk families as compared to patients from BRCA1 or BRCA2 positive families: a retrospective cohort study. Breast Cancer Res. 2012;14:R156. Article PubMed PubMed Central Google Scholar the German Consortium for ...
[37]. Therefore, 42 different pathogenic point mutations inBRCAwere described in the cohorts A, B and C in Brazil. All patients positive forBRCAmutations had a family history of BC (Additional file1: Table S1; Tables1,2). Four different LGRs (3 inBRCA1and 1 inBRCA2) were also ...