based on the scaled Brier score, was the topBRCA2model and the second-rankedBRCA1model (Supplementary Table1). Furthermore, its accuracy was nearly as great when only the positive and negative controls where labeled: the average absolute difference in classification probabilities...
Here, we identify the ubiquitin-specific protease USP21 as a positive regulator of BRCA2, a key mediator of DNA repair by homologous recombination. USP21 interacts with, deubiquitinates and stabilizes BRCA2 to promote efficient RAD51 loading at DNA double-strand breaks. As a result, depletion ...
24,25BRCA2 carriers are more likely to develop estrogen receptor–positive cancers, so their lower contralateral breast cancer risk estimates may in part be due to greater use of endocrine therapy. Hormone and chemotherapeutic treatments were not considered, so the present estimates represent risks ...
represent the mean ± SD of four independent experiments. (ns, not significant).dFrequency of mCherry positive cells in cells transfected with the promoter-less donor plasmid (AAVS1-2A-mCherry) without (−TALEN) (open circles) or with (+TALEN) nucleases (filled circles). The error ba...
Top: correlation matrix of these genes indicating strong positive pairwise correlations within control samples (Pearson’s R = 0.92, 0.91, and 0.89) and modest positive correlations within BRCA2 carriers (Pearson’s R = 0.33, 0.28, 0.27). Sample IDs, age, and parity of the samples are as...
Tamoxifenis a drug that binds to estrogen receptors and blocks their effects in the breasts. For this reason, tamoxifen is used for both the treatment and prevention of estrogen receptor-positive breast tumors. Multiple studies have associated the use of tamoxifen and similar drugs with a reduced...
Gains in LE are consistently lower for women with node-positive disease than for women with node-negative disease. The worse the prognosis of the primary breast cancer, the lower the likelihood a woman will survive to reap the benefits of secondary cancer prevention. Similarly, the potential bene...
That is a one in eight lifetime risk for every woman. One in every 500 women will test positive for the BRCA genetic mutation in their lifetime, making it very rare ("BRCA Gene Mutations"). Testing positive means that genetically, a person has heightened cancer risks.Nilan, Elizabeth...
mechanism can be under separate regulatory control, allowing HSF2BP to serve as a versatile and potent agent increasing the local concentration and/or modifying the oligomerization state of BRCA2. This can play a positive role in some contexts and be detrimental in others. For example, we ...
Given the abundance of conserved positively charged amino acid residues in this region, we term this the ‘positive patch’ (Supplementary Fig. 5). Fig. 2: Cross-linking mass-spectrometry (XL-MS) reveals interactions between the N- and C-terminal halves of Rad52. A Rad52 or B the Rad52...