The cumulative risk of melanoma was 2.5% for BRCA1 carriers and 2.3% for BRCA2 carriers, compared to 1.5% for women in the general population in the United States. The strongest risk factor for skin cancer was a prior diagnosis of skin cancer. Conclusion: The risk of non-melanoma skin ...
In previous study, FGF-5 and FGF-7 were overexpressed in gingival hyperpla... WT Kim,NS Cho,SS Shin,... 被引量: 0发表: 2004年 BIOMARKERS FOR THE EARLY DETECTION OF BREAST CANCER , skin dimpling, nipple inversion, spontaneous single-nipple discharge, a family/personal history of breast ...
The hereditary breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2, have established roles in genome integrity maintenance and in the control of homologous recombination. Recent work has produced valuable insights into the mechanisms of action of the gene products. This review summarizes so...
BRCA1 and BRCA2 are tumor suppressor genes, and germ line mutations in these two genes increase the risk of breast cancer. Both BRCA1 and BRCA2 are required for stabilization and repair of stalled replication forks. Stalled forks, when not resolved, lead to mutations, or collapse into double...
recombination, transcriptional regulation, and chromatin remodeling. Germline mutations in this gene confer a significantly increased risk for both male and female breast cancer, ovarian cancer, fallopian tube carcinoma, uveal tract and skin melanoma, and pancreatic, biliary tract, and prostatic carcinoma...
Minor role of BRCA2 mutation (Exon2 and Exon11) in patients with early-onset breast cancer amongst Iranian Azeri-Turkish women S. Der- akhshan, "Minor role of BRCA2 mutation (Exon2 and Exon11) in patients with early-onset breast cancer amongst Iranian Azeri-Turkish women," ... N ...
Describes a relatively rare subtype of breast cancer that can be defined by immunohistochemistry. These tumours express markers that are typically seen in normal basal breast and skin epithelium, such as cytokeratins 5 and 6. This phenotype is often associated with a poor outcome. Rights and permi...
Breast Cancer Risk Women were included in the estimation of first breast cancer risk if at completion of the baseline questionnaire they had not been diagnosed as having any cancer (excluding nonmelanoma skin cancer) nor undergone risk-reducing bilateral mastectomy (with mastectomy: n = 304 BR...
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1; Prostate cancer, familial; Hereditary Breast and Ovarian Cancer Syndrome; Malignant neoplasm of breast; Pyridoxine-responsive sideroblastic anemia; Nephroblastoma; Fanconi Anemia; Esophageal Atresia; Almond-shaped eyes; Increased chromosomal breakage; Ra...
Genetic Variants in Fanconi Anemia Pathway Genes BRCA2 and FANCA Predict Melanoma Survivaldoi:10.1038/jid.2014.416Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using data derived ...