reports on the findings by researchers from the University of Rochester School of Medicine that BRCA 1/2 genetic testing of women at high risk of carrying the BRCS 1 or 2 gene mutations, and treatment of those who test positive, seems to be cost effective compared with no genetic testing....
The cost of testing and counseling exceeded $2000. The counseling portion of the cost comprised only 16% of the total cost, with the remainder representing costs associated with testing; thus, alternatives to full genetic counseling that shorten counseling time are unlikely to have a large impact...
(UC) methods in terms of knowledge, satisfaction, decisional quality, quality of life, and distress, all while yielding high cost savings to the patient and increasing patient accessibility, studies have also shown that patients randomized...
The comprehensive tumor sequencing effort followed by clinical genetic testing at Dana-Farber/Harvard Cancer Center has not only highlighted the commonness of pathogenic/likely pathogenic mutations in genes such as BRCA1, BRCA2, and PALB2, but has also underscored the significance of this targeted s...
significantly influencing the choice of individualized treatment for patients. Identifying the hotspot mutation ofBRCAin China's Hakka population is advantageous for the development of a targeted testing kit focused on specific sites, enabling faster and more cost-effective testing. In addition to identif...
mutations. Negative BRCA1 immunohistochemical staining, decreased BRCA1 mRNA, lack of PI3K amplification, and absence of BRCA1 promoter hypermethylation is an example of a molecular profile that could be used to identify these patients. This would also allow more cost effective and efficient mutation...
Genetic testing can be accomplished at a lower cost of about $50 –200 in private laboratories (Karen Kaul, personal communication). Thus, if licensing at a lower cost or a discounted commercial cost were negotiated, the cost-effectiveness of a mass screening program would be dramatically higher...
testing for theBRCA1andBRCA2gene mutations?” and were instructed to assume that testing was not covered by their medical insurance. We excluded women who had tested because their response would likely have been influenced by actual cost of testing. The main findings were that subjective numeracy...
The need for fast, efficient, and less costly means to screen genetic variants associated with disease predisposition led us to develop an oligo-nucleotide array-based process for gene-specific single nucleotide polymorphism (SNP) genotyping. This cost-e
testing for BRCA1/2 mutations include cost and insurance coverage, provider awareness, race/ethnicity, concerns regarding insurance discrimination, and psychoso- cial barriers.16–18 The decision to undergo genetic counseling and testing is multifaceted and may be spurred by a desire to understand ...