Males at-risk for the BRCA1- gene, the psychological impact. Psycho Oncology 1996;5:251-257.Dudok de Wit AC, Tibben A, Frets PG, et al. Males at-risk for the BRCA1- gene, the psychological impact. Psych Onc 1996
1. Miki, Y., et al., A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science, 1994. 266(5182): p. 66-71. 2. Wooster, R., et al., Identification of the breast cancer susceptibility gene BRCA2. Nature, 1995. 378(6559): p. 789-92. ...
We identify C16orf72/HAPSTR1/TAPR1 as a gene that is synthetic lethal with PARP1/2 gene disruption and allows cells to tolerate replication stress. Further, we identify that this is achieved though C16orf72 functioning with BRCA1 and Senataxin to allow replication fork progression by ...
散发性卵巢癌中BRCA1基因突变的研究
Mutation screening of the genes identified a duplication of ten nucleotides c.815_824dupAGCCATGTGG, (p.Thr276Alafs) (NM_007294.3) located in exon 11 ofgene, in 15 index cases (allelic frequency 27.7%). The pathogenic variant has been previously reported in African Americans as a founder ...
StudyonmutationtestofBRCA1/2geneof hereditarybreastcancerinXinjiang WuTao,OuJianghua,HamratWufuer,XuWenting,ChenLing,NiDuo (DepartmentofBreastSurgery,AffiliatedTumourHospital, XinjiangMedicalUniversity,Urumqi830011,China) Abstract:Objective KnowingtheBRCAgenemutation’SlOCUSandcarryingsituationofhereditarybreast ...
BRCA1 2 基因检测报告 Genetic Test Report Of BRCA1 2 genes 委委 托托 人人 样本编号 样本编号 接接收收日期 日期 报告日期 报告日期 BRCA1 2 基因检测报告单基因检测报告单 姓名 性别 出生日期 医院 科室 样本编号 样本类型 全血样本状态 合格 不合格 疾病史 乳腺癌临床诊断 卵巢癌临床诊断 否 家族史 乳腺...
Like BRCA2, high expression of p53 gene was observed suggesting that the test drug targets genes maintaining genomic integrity [66,67]. Recent review [68] indicated that co-inactivation of p53 and BRCA1 could lead to tumor formation and development, and could be regarded as signatures of molec...
There are two genes, breast cancer gene 1 (BRCA1) and breast cancer gene 2 (BRCA2), that in rare cases could have an inborn error, a mutation. A mutation in any of these genes might explain why a certain person is affected with breast cancer. In most cases, women with a mutation ...
(1995) have found that the risk of ovarian cancer relative to the risk of breast cancer was higher in families with protein-truncating mutations in the first two-thirds of the gene than in families with protein-truncating mutations in the last one-third of the gene. More recently, Thompson ...