Males at-risk for the BRCA1-gene, the psychological impact. Psycho-oncology 1996; 5: 251 ± 257.DudokdeWit AC, Tibben A, Frets PG, Meijers-Heijboer EJ, Niermeijer MF (1996): Males at-risk for the BRCA1-gene, the psychological impact. Psycho-Oncology 5:251-257....
[Abstract]Germline mutations inBRCAgenes (includingBRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population basedBRCAgene screening, particularly in high-risk individuals with a ...
"Not enough men are getting genetic testing to see if they carry a BRCA1 or BRCA2 gene variant that increases their cancer risk," said lead author Heather Cheng, MD, Ph.D., the director of the Fred Hutch Prostate Cancer Genetics Clinic. "And the men who know they are carriers get tes...
Background: Male breast cancer (MBC) is an uncommon malignancy with an incidence that accounts for about 1% of all breast cancer cases. It commonly presents as a locally advanced tumor that has already spread to the regional nodal basin. Similar to female breast cancers, MBC gene expression pr...
A total of 30 Japanese male patients with advanced or metastatic breast cancer in whom two genes (BRCA1, BRCA2) belonging to the homologues recombination gene family with germline pathogenic variants (gPVs) were detected were recommended for treatment with a PARP inhibitor (i.e., olaparib) or...
[Abstract]Germline mutations in BRCA genes (including BRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population based BRCA gene screening, particularly in high-risk individuals with a family history of cancer, can play a preventive role by reducing ...
The breast cancer susceptibility gene, BRCA2 on chromosome 13q12–13, was recently isolated1–3. Mutations in BRCA2 are thought to account for as much as 35% of all inherited breast cancer as well as a proportion of inherited ovarian cancer1. Many BRC2-l
Google Share on Facebook BRCA1 Also found in:Thesaurus,Medical,Acronyms,Encyclopedia,Wikipedia. Related to BRCA1:BRCA2 n. A gene that is associated with the development of familial breast cancer when inherited in a defective state. [br(east) ca(ncer) 1.] ...
"These data will help to optimize medical care in male BRCA1 and BRCA2 PV carriers," Dr. Ottini said. "In particular, screening and surveillance programs in men with BRCA1 and BRCA2 PVs should be tailored in light of these gene-specific cancer phenotype differences." ...
[Abstract]Germline mutations inBRCAgenes (includingBRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population basedBRCAgene screening, particularly in high-risk individuals with a family history of cancer, can play a preventive role by reducing mortality...