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Intracellular BCKAs are cleared by branched-chain ketoacid dehydrogenase (BCKDH), which is sensitive to inhibitory phosphorylation by BCKD kinase (BCKDK). Accumulation of BCKAs is an indicator of defective BCAA catabolism and has been correlated with glucose intolerance and cardiac dysfunction. However...
建议收到该Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) Antibody产品后,储存温度为-20°C。避免重复冻融其他 Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白质供应商,致力于为生命科学、药物开发和生物技术领域的科学家和研究者提供最佳的客户体验和高质量的产品。产品涵盖一抗、...
branched‐chain α‐ketoacid dehydrogenase complexleucinemTORC1The branched‐chain α‐ketoacid dehydrogenase (BCKDH) complex regulates branched‐chain amino acid (BCAA) catabolism by controlling the second step of this catabolic pathway. In the present study, we examined thein vivoeffects of treatment ...
Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step in BCAA degradation, the activity of which is inhibited by BCKDH kinase (BDK)-mediated phosphorylation. Screening efforts to ...
Branched Chain 2-Oxoacid Dehydrogenase Branched Chain Amino Acid Branched chain amino acids Branched chain amino acids Branched chain amino acids branched chain fatty acids branched chain fatty acids branched chain fatty acids Branched Chain Ketoacid Dehydrogenase Kinase ...
In good accordance with our results, previous studies have also shown that the overexpression of branched-chain ketoacid dehydrogenase kinase in the liver during BCAA metabolism can increase ATP-citrate lyase phosphorylation and stimulate de novo fat synthesis. The gut microbiota fundamentally influences ...
GCN2 is Essential for Oligodendrocyte Development and Myelination in the Brains of Mice Born Deficient in Branched-Chain α-Ketoacid Dehydrogenase Kinase (BDK)The eukaryotic initiation factor 2 (eIF2) kinase, GCN2, is critical for surviving branched chain amino acid deficiency during early postnatal...