The first steps in their catabolism are common to all three, involving the BCAA aminotransferase (BCAT) and branched-chain alpha-keto acid dehydrogenase (BCKD). Their further metabolism employs distinct pathways to different end-products (glucose and/or ketone bodies). However, the fact that the...
The catabolic pathway for branched-chain amino acids (BCAAs) include deamination followed by oxidative decarboxylation of the deaminated product branched-chain α-keto acids (BCKAs), catalyzed by mitochondrial branched-chain aminotransferase (BCATm) and branched-chain α-keto acid dehydrogenase enzyme ...
et al. Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms. Arch. Biochem. Biophys. 407, 231–240 (2002). CAS PubMed Google Scholar Shimomura, Y. et al. Branched-chain 2-oxo acid dehydrogenase complex activation by tetanic contractions in rat skeletal muscle....
active system for the degradation of the α-branched-chain-keto acids (BCKA) derived from the corresponding BCAAs (Nicastro et al., 2012) by the branched-chain α-keto acid dehydrogenase (BCKD)enzyme, which contribute togluconeogenesis(Newsholme et al., 2014)....
Furthermore, PDAC cell proliferation, but not HPDE cell proliferation, was substantially inhibited upon knockdown of branched-chain α-keto acid dehydrogenase a (BCKDHA). Interestingly, BCKDHA knockdown had no significant effect on mitochondrial metabolism; that is, neither the level of tricarboxylic ...
Branched amino acid preferring peptidase Branched Calculus branched chain Branched Chain 2-Oxoacid Dehydrogenase Branched Chain Amino Acid Branched chain amino acids Branched chain amino acids Branched chain amino acids branched chain fatty acids
Branched-chain α-ketoacid dehydrogenase BCAA: Branched-chain amino acid DG: Dysglycaemia (group) FFM: Fat-free mass FFQ: Food frequency questionnaire GIR: Glucose infusion rate 3-HIB: 3-Hydroxyisobutyrate LAT1: Large amino acid transporter NG: Normoglycaemia (group) ScWAT: Subc...
amino acid n. Any of various compounds containing an amino group (NH2), a carboxylic acid group (COOH), and a distinctive side chain, especially any of the 20 amino acids that link together to form proteins. Some amino acids (called nonessential) can be synthesized in the human body, whi...
Branched-chain amino acid (BCAA)Type 2 diabetes mellitusBranched-chain -keto acid dehydrogenase (BCKDH) compThe branched-chain 伪-keto acid dehydrogenase (BCKDH) complex is the most important regulatory enzyme in branched-chain amino acid (BCAA) catabolism. We examined the regulation of hepatic ...
(Supplementary Fig.1a, b), and the changes of the key enzymes were confirmed by real-time PCR (Fig.1b, c)26. The mRNA levels of branched-chain amino acid transaminase 2 (BCAT2) and branched-chain alpha-keto acid dehydrogenase (BCKDH) complex, two enzymes that catalyzed the initial and...