Human splicing branchpointLogistic regressionAlternative splicing is the critical process in a single gene coding, which removes introns and joins exons, and splicing branchpoints are indicators for the alternative splicing. Wet experiments have identified a great number of human splicing branchpoints, ...
Is the log sequence number of the current fork point. 是当前分叉点的日志序列号。 权威例句 Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A. Splice junctions, branch point sites, and exons: sequence statistics, identification, and...
We show here that a branchpoint sequence from a human globin gene (5′-CTGACTCTCTCTG-3′)11greatly enhances the efficiency of splicing of a ‘synthetic’ intron in HeLa cells. A mutated branchpoint sequence, 5′-CTCCTCTCTCTG-3′, in which the branchpoint acceptor nucleotide A has been ...
真核生物pre-mRNA splicing过程中,下列不正确的是( ) A. 供体端的G碱基与分支点(branch point)的A碱基形成2’,5’-磷酸二脂键 B. U1 snRNA与Intorn5’序列形成碱基配对 C. 剪接后Intorn形成一个Lariat(套索)结构 D. 任何情况下,所有的Intorn都会被剪接掉 相关知识点: 试题来源: 解析 D 反馈 收藏 ...
Thus, a very short intron lacking a classical pyrimidine tract between the branch point and 3' splice site requires accessory pyrimidine sequences in the short region between the 5' splice site and branch point. 展开 关键词: Insect Hormones Introns Nuclear Proteins Pyrimidines RNA Splicing ...
Wobble splicing regulation at tandem splice sites Moreover, we found that the NAGNAG motif and its upstream region to the branch point sequence play an important role in 3' splice site selection for NAGNAG wobble splicing. Mutations in the region between the branch site and the ... KW Tsai...
Analysis of RNase TI-resistant fragments immunoprecipitated by an anti-(U2)RNP antibody at early times of the splicing reaction showed that the protection encompasses both the branch point region and the end of the intron in BamHl and Avall, but essentially only the branch point in Accl RNAs....
英文名:SF1 (Splicing Factor 1, Mammalian Branch Point-binding Protein, BBP, mBBP, Transcription Factor ZFM1, Zinc Finger Protein 162, ZFM1, ZNF162) (MaxLight 750) 中文名: CBNumber:CB04973311 分子式: 分子量:0 MOL File:Mol file SF1 (Splicing Factor 1, Mammalian Branch Point-binding Protei...
the translocated helicase domain of PRP5 stays with U2 snRNA and the acidic loop still occupies the RNA path. The pre-A conformation is specifically stabilized by the splicing factors SF1, DNAJC8 and SF3A2. Cancer-derived mutations in SF3B1 damage its association with PRP5, compromising BS ...
Pladienolide, herboxidiene and spliceostatin have been identified as splicing modulators that target SF3B1 in the SF3b subcomplex. Here we report that PHF5A, another component of this subcomplex, is also targeted by these compounds. Mutations in PHF5A-Y3