Plant molecular biologyAlternative splicing (AS) promotes transcriptome and proteome diversity during growth, development, and stress responses in eukaryotes. Genome-wide studies of AS in sugarcane (spp.) are lacking, mainly due to the absence of a high-quality sequenced reference genome, sugarcane's...
A. The roles of RNA processing in translating genotype to phenotype. Nat. Rev. Mol. Cell Biol. 18, 102–114 (2017). Article CAS PubMed Google Scholar Stern, D. L. Perspective: Evolutionary developmental biology and the problem of variation. Evolution 54, 1079–1091 (2000). Article CAS...
Beyond gene-level information, RNA processing within a gene also holds rich information for both categorical cell states and continuous cell differentiation. A key RNA processing step is splicing, where a precursor mRNA (pre-mRNA or unspliced RNA) is spliced by removing intronic, non-coding region...
In most cases, these variants result from aberrant splicing, which produces proteins that alter, often favoring, critical aspects of cancer cell biology [43], [44], [45]. Besides generating abnormal proteins, AS can produce aberrant forms of mRNAs containing “poison exons”, which lead to ...
biology and disease. We found islet sQTLs that impact genes that have major roles in islet cell function as well as in the pathophysiology or treatment of various forms of diabetes. Furthermore, we observed a selective inflation of T2D association p-values among sQTLs, some of which showed ...
The mossPhyscomitrella patensis a common model organism in systems biology44,45,46. Moss has two life forms – filamentous protonemata representing the juvenile stage, and leafy gametophores representing the adult stage. Protonema filaments are used as a source of protoplasts, which are an ideal ...
its function in tumor biology. The isoform expression variation for RAC1 was also shown by the box plot (Fig.3). Primary solid tumor tissues had higher uc003spw.3 transcript expression, while there was lower uc003spx.3 transcript expression relative to normal tissues (Fig.3a and b) ...
In conclusion, we detected novel tissue- and cancer-related splicing in a number of genes and validated these on independent sample sets, indicating the potential importance of the variants for cancer cell biology and the potential utilization of the cancer-specific variants as biomarkers and drug ...
PLOS Biology 2007 Splicing and the Evolution of Proteins in Mammals DOI: 10.1371/journal.pbio.0050014 Joanna L Parmley,Araxi O Urrutia,Lukasz Potrzebowski,Henrik Kaessmann,Laurence D Hurst Full-Text Cite this paper Add to My Lib Abstract: It is often supposed that a protein's rate of ...
A. et al. hnRNP A/B proteins: an encyclopedic assessment of their roles in homeostasis and disease. Biology 10, 712 (2021). Article CAS PubMed PubMed Central Google Scholar Van Nostrand, E. L. et al. A large-scale binding and functional map of human RNA-binding proteins. Nature 583...