M. Dom- browski, "Brain cancer stem cells in adults and children: cell biology and therapeutic implications," Neurotherapeu- tics, vol. 14, no. 2, pp. 372-384, 2017.Abou‑Antoun TJ, Hale JS, Lathia JD and Dombrowski SM: Brain cancer stem cells in adults and children: Cell...
In the last decade, several groups have demonstrated the existence of cancer stem cells in both nonsolid solid tumors, including some of the brain: glioblastoma multiforme (GBM), medulloblastoma, and ependymoma. These cells, like their normal counterpart in homologous tissues, are multipotent, ...
Brain cancer can be either nonmalignant (low-grade tumors) or malignant (high-grade tumors), with glioblastomas being the most aggressive and prevalent malignant brain cancer in adults. Understanding the molecular features and pathways involved in brain cancer is crucial for improved diagnosis, ...
Brain Cancer stem cells as potential research and therapeutic target in treatment of Glioblastoma Multiforme (GBM) Primary brain tumors account for less than 2% of all cancers in adults; however, they are often associated with neurologic... J Sharma,R Punzalan,M Majdoub,... - 《Cancer Research...
In a study of 103 patients with WHO grade II tumors, expression of the PDGF receptor was correlated with a poorer prognosis and was typically associated with oligodendrogliomas.6The ability of PDGF to dedifferentiate mature cells, or its role in the promotion of cancer stem cells, is not cle...
We will also discuss preclinical models and their clinical translation as well as the challenges of CAR T-cell therapy for brain cancer. 3. Adult brain tumors 3.1. Glioblastoma GBM is the most prevalent and lethal primary brain tumor in adults, with an incidence of 3.19 per 100,000 ...
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University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points the way to more effective future
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