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High mutational burden in autistic females A study of more than 9,000 dizygotic twins from population-based cohorts showed that siblings of autistic females exhibit significantly more autistic traits than siblings of autistic males [58-60], suggesting that female patients carry a higher ‘genetic loa...
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Secondary, intracranial brain insults include cerebral edema, hematomas, hydrocephalus, intracranial hypertension, vasospasm, metabolic derangement, excitotoxicity, calcium ions toxicity, infection, and seizures [9, 10]. Secondary, systemic brain insults are mainly ischemic in nature [9, 11], such as:...
This improvement was maintained over 30 days with DBS40PW while providing effective tremor suppression in six out of seven patients. Conclusion Shorter pulse widths may reduce gait disturbances in patients with ET that are induced by DBS while preserving a level of tremor suppression equal to ...
Lysosomes sense nutrient availability through the activities of V-ATPase and the conserved serine–threonine kinase, mTORC1, and both are sensitive to changes in amino acid levels [2,8]. The activity of the V-ATPase is regulated through association–dissociation of its many subcomplexes [9]. In...
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