The actin cytoskeleton is a key determinant of cell structure and homeostasis. However, possible tissue-specific changes to actin dynamics during aging, notably brain aging, are not understood. Here, we show that there is an age-related increase in filam
microglia foster a pro-inflammatory environment. Similar to macrophages, microglia derive from myeloid precursor cells, and can further differentiate from monocytes into a pro-inflammatory M1 microglia phenotype or an anti-inflammatory/restorative M2 microglia form. Following TBI, the M1-like phenotype...
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Following primers were used to specifically detect the transgene alone: forward 5'-GAG-CTG-GTT-TAG-TGA-ACC-GTC-3' and reverse 5'-CTT-TAT-CTG-TGA-ATC-CAC-GGC-CAT-TC-3'. The forward primer is complementary with the CMV promoter, and the reverse primer is complementary to MK5 sequences...
[66,70], an important cause is also mortality in patients with poor neurological function. In a multicentre study on 980 patients discharged alive from hospitals in North America, the adjusted hazard ratio for long-term survival in patients with CPC 2, 3, and 4 at hospital discharge compared...