Liu , Chunyu : Brain expression quantitative trait locus mapping informs genetic studies of psychiatric diseases. Neurosci Bull 2011, 27(2):123-133.Liu, C. (2011). Brain expression quantitative trait locus mapping informs genetic studies of psychiatric diseases. Neuroscience Bulletin, 27(2), 123...
613 RNA-sequencing samples from 14 brain datasets to create the MetaBrain resource and performedcis- andtrans-expression quantitative trait locus (eQTL) meta-analyses in multiple brain region- and ancestry-specific datasets (n ≤
expression quantitative trait locus FA: Formic acid soluble tissue fraction FDR: False Discovery Rate GAC: Genome analysis core GBR: British in England and Scotland population GO: Gene ontology GWAS: Genome-wide association study GWS: Genome-wide significant HRC: Haplotype reference consort...
While large-scale, genome-wide association studies (GWAS) have identified hundreds of loci associated with brain-related traits, identification of the variants, genes and molecular mechanisms underlying these traits remains challenging. Integration of GWAS with expression quantitative trait loci (eQTLs) an...
FUMA38software applied three strategies to annotate candidate SNPs to genes at significantly associated loci (Methods): physical position, expression quantitative trait locus (eQTL) information and chromatin interactions (Supplementary Table12and Supplementary Figs.4and5). Here we summarize and cite notable...
46 Chorney M, Chorney K, Seese N et al.: A quantitative trait locus associated with cognitive ability in children. Psychol. Sci. 9(3), 1–7 (1998). 47 Killian J, Nolan C, Wylie A et al.: Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary. Hum....
In addition, we used E-MAGMA (expression quantitative trait loci [eQTL]–informed MAGMA)49 and transcriptome-wide association study analysis using joint-tissue imputation50 to further investigate the tissue-specific genes, parallelized with H-MAGMA (Hi-C–coupled MAGMA)51 to indicate the cell-type...
Together, our findings will guide the design of both genome-wide haplotype mapping and more targeted F2 quantitative trait locus mapping to reveal complex genetic networks driving the risk/resilience of these TBI outcomes. It is also possible to finally translate the findings of genetic mapping ...
Figure 1. Module Quantitative Trait Loci (ROSMAP) Summary of the GWAS of gene co-expression module levels in the primary dataset (ROSMAP DLPFC, n = 494). The circos plot displays five independent Manhattan plots: each colored sector represents a Manhattan plot summarizing the GWAS result for ...
150) also had sex-differentiated protein abundance (Supplementary Table8). Our findings at the protein level are comparable with published findings at the transcript level, in which 14% of the sex-biased expression quantitative trait locus (sb-eQTL) transcripts also had sex-biased mRNA expression...