Physiological changes occurring in experimentally induced chronic ischemic areas of the brain in monkeys have been investigated by measuring local cerebral blood flow (1CBF) and recording somatosensory evoked potentials (SEPs) to median nerve stimulation in the cortex and thalamus (VPL). Ischemia was ...
Magnetic resonance imaging revealed no new ischemic lesions and no abnormal findings in the cerebral arteries. Repeated 123I-iomazenil SPECT showed resolution of the relative increases and decreases in tracer uptake in the left cerebral hemisphere on early and late images, respectively, that were ...
Multiple sclerosis (MS) is a chronic autoimmune disease characterized by demyelination, gliosis, neurodegeneration in the CNS and inflammation [95]. Although it is not an autoimmune disease, amyotrophic lateral sclerosis (ALS) also results in similar degeneration but specifically in motor neurons. Neu...
The voltage-gated K+-channel α subunit Kv9.1 encoded by the KCNS1 gene up-regulated in human pyramidal cells in the Pressure group has been found to be associated with multiple chronic pain states [9], however, interpretation of our findings is difficult knowing that electrically silent Kv9.1...
Contrary to these results, in rodent models of ischemic injury, chronic, physiological concentrations of E2 protected the cortex againstMiddle Cerebral Artery Occlusion(MCAO)-induced damage without effecting CBF (Alkayed et al., 2000; Dubal and Wise, 2001; Rusa et al., 1999). These findings we...
These ex vivo and in vitro approaches underline the importance of cell and electric field orientation, cell morphology, cell location within populations, stimulation duration (acute, prolonged, chronic), and molecular changes, such as Ca2+-dependent intracellular signaling pathways, for the effects of...
Ischemic stroke can have devastating consequences to individuals and their families while simultaneously carrying a high social and economic burden. Major advances have been achieved in prevention and treatment of stroke by means of population-health management of risk factors and acute interventions. Inno...
Biofilm production results in higher antimicrobial resistance and allows chronic colonization of P. aeruginosa in the host [11]. An increased abundance of P. aeruginosa has been found in the nose of patients with COVID-19, which was positively associated with viral RNA load [12]. P. ...
摘要: Inflammatory processes and cytokine expression have been implicated in the pathogenesis of several neurodegenerative disorders. Chronic ethanol intake induces brain damage, although the mechanisms involved in this effect are not well understood....
These changes were specific for the newborn neurons and were not observed when estimating the overall expression of gephyrin, NL-2, and GABAAR-α2 in the hippocampal GCL. The expression of interleukin-1-type 1 receptor (IL-1R1) on preferentially the somatic region of new neurons, often in ...