Alternatively, changes in the SCD group may be at an undetectable level, and dysregulation of long term potentiation or synaptic losses46 could justify memory complaints, before neuronal death and quantifiable atrophy. This subtends the need and importance to follow this cohort longitudinally to ...
Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer’s disease Nuanyi Liang, Kwangsik Nho, John W. Newman, Matthias Arnold, Kevin Huynh, Peter J. Meikle, Kamil Borkowski, Rima Kaddurah-Daouk & the Alzheimer...
Results 21-day SM decreased brain derived neurotrophic factor and induced neuron atrophy in the cerebral cortex. Strong oxidative stress was triggered at day 7 and the oxidative status returned to physiological level at day 21. Inflammatory cytokines were gradually suppressed and in striatum, the supp...
The effects of stress on hippocampal neurogenesis and synaptogenesis are also sexually dimorphic. Chronic restraint stress produces atrophy of the dendritic tree of CA3 neurons, exclusively in the apical field in males and only in the basal field in females [184]. Chronic stress impairs cell prolife...
https://doi.org/10.1016/j.neuroimage.2020.117596Get rights and content Under a Creative Commons license open accessHighlights Abstract We address the problem of estimating how different parts of the brain develop and change throughout the lifespan, and how these trajectories are affected by genetic...
(when the brain bounces back and forth or sideways within the cranium). TBI seldom affects a single area of the brain and often leads to diffuse damage which explains the multitude of physical, social, cognitive, and psychiatric symptom presentations postinjury.Cerebral atrophyhas been observed up...
Region-specific hierarchy between atrophy, hypometabolism, and β-amyloid (Aβ) load in Alzheimer’s disease dementia. J Neurosci. 2012;32(46):16265-16273.PubMedGoogle ScholarCrossref 16. Saint-Aubert L, Nemmi F, Péran P, et al. Comparison between PET template-based method and MRI-...
hippocampal volumes [87]. The short-term increased brain tissue volume and lack of long-term or permanent atrophy in our model can be explained by the lack of diffuse axonal injury; DTI and NODDI detecting no changes characteristic of diffuse axonal injury in our model and the correlation ...
The medulla oblongata regulates cardiovascular and respiratory function and atrophy and lesions of medulla oblongata and the other brainstem structures are hallmarks of neurological disorders5,6,8. Despite their importance in human health and disease, the brainstem regions remain markedly understudied. ...
brain atrophy and microglial activation was also demonstrated; thus, we showed that severe stress could cause sensitisation in the visual cortex and the thalamus, both at the microscopic level and at the macroscopic level of brain atrophy detection using MRI. Interestingly, atrophy in the bilateral ...