参考文献: 1. Wang X, Zhao C, Gong Y, Wang Y, Guo F. Multidrug resistance in the standardized treatment of colon cancer harboring a rare fibrosarcoma B-type (BRAF) p.N581I mutation: a case report. Front Oncol. ...
We have explored survival difference in right-sided colon cancer (RCC) patients according to BRAF mutations, with the aim to identify any predictive factors of response to targeted-based therapy.MethodsA retrospective study of RCC patients, with BRAF known mutation status, treated with chemotherapy ...
Van Cutsem, E., Köhne, C.-H., Láng, I., Folprecht, G., Nowacki, M. P., Cascinu, S. et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumorKRASandBRAFmutation stat...
可能还有其他基因突变导致了随后的耐药及骨和小脑的远处转移。 参考文献:Wang X, Zhao C, Gong Y, Wang Y and Guo F (2023) Multidrug resistance in the standardized treatment of colon cancer harboring a rare fibrosarcoma B-type (BRAF) p.N581I mutation: a case report. Front. Oncol. 13:1175693...
Rather, this early establishment of RAS status is appropriate to plan for the treatment continuum【 [kənˈtɪnjuəm] 连续体】, so that the information may be obtained in a non– time-sensitive manner and ...
[10] Dienstmann R, Mason MJ, Sinicrope FA, et al. Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study. Ann Oncol 2017; 28: 1023–1031. [11] Hamilton SR. BRAF mutati...
Predictive and prognostic roles of BRAF mutation in stage Ⅲ colon cancer: results from intergroup trial CALGB89803 [J]. Clin Cancer Res, 2012, 18(3):890-900. [15] Pai R K, Jayachandran P, Koong A C, et al. BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an ...
参考文献:Wang X, Zhao C, Gong Y, Wang Y and Guo F (2023) Multidrug resistance in the standardized treatment of colon cancer harboring a rare fibrosarcoma B-type (BRAF) p.N581I mutation: a case report. Front. Oncol. 13:1175693. doi: 10.3389/fonc.2023.1175693...
celllines:thecoloncancercelllineHT-29,inwhichisasso-clearsynergisticeffectofthesecompounds(Fig.3b).Thus,theforma- ciatedwithanactivatingPI(3)K(P449T)mutation9andEGFRover-tionoftheeIF4Fcomplexisdirectlyinvolvedinsensitivitytovemurafenib. expression10;andthepapillarythyroidcancercelllineBCPAP,inwhichTargetingtr...
参考文献:Wang X, Zhao C, Gong Y, Wang Y and Guo F (2023) Multidrug resistance in the standardized treatment of colon cancer harboring a rare fibrosarcoma B-type (BRAF) p.N581I mutation: a case report. Front. Oncol. 13:1175693. doi: 10.3389/fonc.2023.1175693 ...