MutationGene Regulatory NetworksThere has been much recent progress in our understanding of the role played by the RAS–RAF–MEK–ERK cascade in human cancer. RAS is an oncogene and this pathway is known to promote proliferation and malignant transformation. More recently, however, RAF has become...
[27] Ben T. et al., Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer. Cancer. 2011 Oct 15;117(20):4623-32. [28] Paul L. et al., Microsatellite instability and BRAF mutation testing in colorectal cancer ...
随着对肿瘤分子水平研究的不断深入,BRAF突变已被确定为各种恶性肿瘤生长的驱动因素,其中BRAF V600突变在肺癌中占2%-4%。临床对于携BRAF突变非小细胞肺癌(NSCLC)的治疗,使用传统的化疗或新型的免疫治疗,疗效获益有限,而达拉非尼+曲美替尼(简称“D+T”...
随着对肿瘤分子水平研究的不断深入,BRAF突变已被确定为各种恶性肿瘤生长的驱动因素,其中BRAF V600突变在肺癌中占2%-4%。临床对于携BRAF突变非小细胞肺癌(NSCLC)的治疗,使用传统的化疗或新型的免疫治疗,疗效获益有限,而达拉非尼+曲美替尼(简称“D+T”)方案是针对BRAF突变晚期NSCLC患者的首个双靶药物,已得到国内外...
[2]Luu L J,Price T J.BRAF Mutation and Its Importance in Colorectal Cancer[M]//Advances in the Molecular Understanding of Colorectal Cancer.IntechOpen,2019. [3]Jones J C,Renfro L A,Al-Shamsi H O,et al.Non-V600BR...
[2]Luu L J,Price T J.BRAF Mutation and Its Importance in Colorectal Cancer[M]//Advances in the Molecular Understanding of Colorectal Cancer.IntechOpen,2019. [3]Jones J C,Renfro L A,Al-Shamsi H O,et al.Non-V600BRAF mutations define a clinically distinct molecular subtype of metastatic colo...
[2]Luu L J,Price T J.BRAF Mutation and Its Importance in Colorectal Cancer[M]//Advances in the Molecular Understanding of Colorectal Cancer.IntechOpen,2019. [3]Jones J C,Renfro L A,Al-Shamsi H O,et al.Non-V600BRAF mutations define a clinically distinct molecular subtype of metastatic colo...
【关键词】 肺肿瘤; 非小细胞肺癌; BRAF; BRAF V600; BRAF 抑制剂; 丝裂原活化蛋 白激酶抑制剂 DOI:10.3760 / cma.j.cn112152⁃20230117⁃00030 Expert consensus on the diagnosis and treatment in advanced non⁃small cell lung cancer with BRAF mutation in China Lung Cancer Professional Committee...
Do KH, Nguyen TV, Nguyen Thi Bich P, etc. Successful first-line pembrolizumab combined with chemotherapy in PD-L1-negative non-small cell lung cancer with a rare BRAF mutation: a case report and review of the literature [J]. Case reports in Respirology, 2023, 11(6): e01155 . ...
4. Tie J, Gibbs P, Lipton L, et al: Optimizing targeted therapeutic development: Analysis of a colorectal cancer patient population with the BRAF(V600E) mutation.Int J Cancer 128:2075-2084, 2011 5. Clarke CN, Kopetz ES: BRAF mutant colorectal cancer as a distinct subset of colorectal ...