Mutated BRAF proteins have elevated kinase activity and are transforming in NIH3T3 cells. Furthermore, RAS function is not required for the growth of cancer cell lines with the V599E mutation. As BRAF is a serine/threonine kinase that is commonly activated by somatic point mutation in human ...
Cheng W, Liu R, Zhu G, etc.Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer Cells. J Clin Endocrinol Metab. 2016 Mar;101(3):962-71. Liu J, Liu R, Shen ...
8. Corcoran, R. B. et al. BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation. Sci. Signal. 3, ra84 (2010).9. Ahronian, L. G. et al. Clinical acquired resistance to RAF inhibitor combinations in BRAF-mutant colore...
BRAF基因突变与甲状腺癌关系的研究进 展 广东医学2009年7月第3O卷第7期 GuangdongMedicalJournalJu1.2009,Vo1.30,No.7 [5]wUL,GRIFFINJD.ModulationofNotchsignalingbymaster- mindlike(MAML)transcriptionalco—activatorsandtheirinvolve— mentintumorigenesis[J].SeminCancerBiol,2004,14(5): 348—356. [6]KOVALLRA...
Expert Committee on Tumor Biomarkers of Chinese Society of Clinical Oncology, Expert Group of Expert Consensus on EGFR T790M Gene Mutation Detection in Non⁃Small Cell Lung Cancer Patients in China. Expert consensus on EGFR T790M gene mutation detection in Chinese patients with non⁃small cell ...
2. Davies H, Bignell GR, Cox C, et al: Mutations of the BRAF gene in human cancer. Nature 417:949-954, 2002 3. Loupakis F, Ruzzo A, Cremolini C, et al: KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type ...
◆All patients with metastatic colorectal cancer should have tumor tissue genotyped for RAS (KRAS and NRAS) and BRAF mutations individually or aspart of an NGS panel. 所有转移性结直肠癌患者都应对肿瘤组织进行RAS(KRAS和NR...
differentiationandapoptosis.TheexpressionofTGF-β isenhancedinthyroidcancercells,whosefunctionispromotingdifferentiationand invasion.TherelationshipbetweenBRAFT1799Agenemutationandtheabnormal expressionofTGF-βremainscontroversial.Thepurposeofthisstudyistoclarifythe associationbetweenBRAFT1799AgenemutationandTGF-βexpression...
Hypermethylation of the DNA mismatch repair gene hMLH1 and its association with lymph node metastasis and T1799A BRAF mutation in patients with papillary thyroid cancer[J]. Cancer, 2008, 113(2):247-255. 38. 宝荣, 邵华, 成建新, 等. 甲状腺乳头状癌中DNA修复基因hMLH1的甲基化与BRAF突变...
the mutation ratewas 4.1 7%.Conclusion The mutation rate of KRAgene was high in the tissues of colorectalcancer patients,but the mutation rate of NRAS and BRAF genes was low,but it should not beignored.With the further research of gene mutation,it is more effective to guide the individual—...