Disclosed are cellular compositions, grafts and pharmaceutical products made from bone marrow (BM) cells useful for a wide array of cell-based therapies for diseases and disorders of the nervous system. Transgenic cells in accord with the invention express therapeutic or reporter genes encoded in ...
--- TranslatedbyChenxiangtao,AnhuiMedicalUniversityE-mail:chenxiangtao@21cn 第1页共14页 Bonemarrow-derivedmesenchymalstemcells 骨髓源性间充质干细胞 KEVINC.KEMP,JILLHOWS&CRAIGDONALDSON CentreforResearchinBiomedicine,FacultyofAppliedSciences,UniversityoftheWestofEngland,Bristol,UK 摘要人类间充质干细胞(MSC)...
Mesenchymal stem cells (MSCs) are recruited from BM to the stroma of developing tumors, where they serve as critical components of the tumor microenvironment by secreting growth factors, cytokines, and chemokines. The role of MSCs in colorectal cancer (CRC) progression was controversial. In this ...
The contribution of bone marrow-derived cells to the development of renal interstitial fibrosis. Recent evidence suggests that bone marrow (BM)-derived cells may integrate into the kidney, giving rise to functional renal cell types, including endotheli... J Li,JA Deane,NV Campanale,... - 《...
These results suggest that infiltration of BM-derived monocytic cells into the brain contributes to the development of microglial reaction in AD. 展开 关键词: Microglia β-amyloid Alzheimer's disease Transgenic Bone marrow Transplantation Recruitment Inflammation ...
Bone Marrow–Derived Cells Contribute to Tumor Angiogenesis: the Role of Myeloid Cells Distinct populations of bone marrow–derived cells contribute totumor angiogenesis. Endothelialprogenitor cells(EPCs) incorporate into the vessel wall, andpericyteprogenitor cells (PPCs) surroundendothelial celllinings. In...
This article presents information on bone marrow-derived stem cells for ischemic hearts. Congestive heart failure remains a major public health problem. As new modalities have emerged which have enabled significant reduction in early mortality from acute myocardial infarction there has been a paradoxical...
Non-malignant cells found within neoplastic lesions express alanyl (membrane) aminopeptidase (ANPEP, best known as CD13), and CD13-null mice exhibit limited tumor growth and angiogenesis. We have recently demonstrated that a subset of bone marrow-derived CD11b+CD13+ myeloid cells accumulate within...
Here, we report that p27(Kip1) plays a major role in cardiovascular disease through its effects on the proliferation of bone marrow-derived (BM-derived) immune cells that migrate into vascular lesions. Lesion formation after mechanical arterial injury was markedly increased in mice with homozygous...
The aim of this study was to clarify the role of bone marrow-derived stromal cells (BM-SCs) expressing CD271 in the development of gastric cancer. The effect of human BM-SCs on the proliferation and motility of six gastric cancer cell lines, OCUM-2M, OCU