Bone Marrow Derived Myeloid Suppressor Cell (BM-MDSCs) Prolongs the Graft Survival in Murine Heart TransplantationPurpose To investigate the impact of BM-MDSCs on murine heart transplantation. Material and Methods Bone marrow cells were harvested and cultured with granulocyte-macrophage colony-stimul...
Myeloid-derived suppressor cells (MDSC) are one of the major factors limiting the immune response in cancer. However, their role in bone marrow (BM), the site of primary localization of multiple myeloma (MM), is poorly understood. In this study, we found a significant accumulation of CD11b...
Bone marrow–derived mononuclear cells, which include HSCs, MSCs, endothelial progenitor cells, and precursor cells, also have been used for the treatment of pressure ulcers (Fig. 13.3) [93]. Patients with type IV chronic pressure ulcers (n = 22) at different sites have been treated with app...
Aplastic anemia (AA) is a blood disorder resulted from over-activated T-cell related hematopoietic failure, with the characterization of hypocellularity and enhanced adipogenic differentiation of mesenchymal stroma cells (MSCs) in bone marrow (BM). However, little is known about the relationship betwee...
Bone Marrow–Derived Cells Contribute to Tumor Angiogenesis: the Role of Myeloid Cells Distinct populations of bone marrow–derived cells contribute totumor angiogenesis. Endothelialprogenitor cells(EPCs) incorporate into the vessel wall, andpericyteprogenitor cells (PPCs) surroundendothelial celllinings. In...
E. III Myeloid-derived suppressor cells in breast cancer. Breast Cancer Res. Treat. 140, 13–21 (2013). CAS PubMed PubMed Central Google Scholar Welte, T. et al. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat. Cell Biol. 18, 632–...
The percentage of Gr-1+CD11b+ myeloid-derived suppressor cells (MDSCs) and IFN-γ+ T cells were observed in peripheral blood (PB) and bone marrow (BM) by Flow Cytometry. BMSCs were co-cultured in vitro with tumor cells and MDSCs in a tumor conditioned medium separately in order to ...
Inhibition of B Lymphopoiesis by Adipocytes and IL-1–Producing Myeloid-Derived Suppressor Cells B lymphopoiesis declines with age, and this decline correlates with increased adipose tissue in the bone marrow (BM). Also, adipocyte-derived factors are k... DE Kennedy,KL Knight - 《Journal of Immu...
GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1-bone marrow progenitor cells into myeloid-deriv... Recent reports have shown the involvement of tumor burden as well as GM-CSF in supporting myeloid-derived suppressor cells (MDSC). Howe...
Connexin43 expression in bone marrow derived cells contributes to the electrophysiological properties of cardiac scar tissue Carolina Vasquez, Valeria Mezzano, Newman Kessler, Freja Swardh, Desiree Ernestad, Vanessa M. Mahoney, John Hanna & Gregory E. Morley Scientific Reports volume 10, ...