CLL cell longevity is dependent on external signals, originating from cells in their microenvironment including secreted and surface-bound factors. Dendritic cells (DCs) play an important part in tumor microenvironment, but their role in the CLL bone marrow (BM) niche has not been studied. We ...
Remarkably, bone marrow CLL cells expressed high levels of VEGF and high VEGF levels were detected in the plasma of patients with untreated CLL and correlated with white blood cell count. CLL bone marrow biopsies revealed increased microvascular density and attachment of CLL cells to endothelial ...
Reprints and permissions About this article Cite this article CLL. Bone Marrow Transplant 23 (Suppl 1), S52–S54 (1999). https://doi.org/10.1038/sj.bmt.1701687 Download citation Published15 March 2000 Issue Date01 March 1999 DOIhttps://doi.org/10.1038/sj.bmt.1701687 Springer Nature Limited...
Wang JB, Liu DH, Huang XJ; Chinese Blood and Marrow Transplantation Registry Group. Hematopoietic stem cell transplantation activity in China 2019: a report from the Chinese Blood and Marrow Transplantation Registry Group. Bone M...
TREATMENT OF APLASTIC ANÆMIA BY ANTILYMPHOCYTE GLOBULIN WITH AND WITHOUT ALLOGENEIC BONE-MARROW INFUSIONS. By - B. Speck, E. Gluckman, H.L. Hark, J.J. V... M Serrano,GG Vargas - 《Biomed Research International》 被引量: 11发表: 2013年 Use of icariin in preparing medicine for preven...
The central role of the endothelial microenvironment in orchestrating bone marrow (BM) homeostasis and hematopoietic support has been confirmed at various developmental stages and in adult life. The BM vasculature is crucial in mediating communication be
2. The cellular diversity of the bone marrow microenvironment 3. Metabolic interactions between stromal and blood cancer cells 4. Metabolic interactions between stroma and metastatic solid tumor cells 5. Conclusions & future perspectives Declaration of competing interest Acknowledgements Funding Data availabil...
marrow sections of 35 patients with chronic lymphocytic leukemia (CLL) (infiltration patterns: interstitial 8, nodular 6, mixed 9, diffuse 12) and 13 cases of low grade non Hodgkin's lymphoma (NHL) (centroblastic/centrocytic 7, centrocytic 3, lymphoplasmacytoid 3) with bone marrow ...
Mixed chimerism: preclinical studies and clinical applications. Biol Blood Marrow Transplant 1999; 5: 192–203. CAS PubMed Google Scholar McClune BL, Weisdorf DJ . Reduced-intensity conditioning allogeneic stem cell transplantation for older adults: is it the standard of care? Curr Opin Hematol ...
Immunohistochemical evaluation of neoplasms in bone marrow biopsies using monoclonal antibodies reactive in paraffin-embedded tissue. A panel of commercially available monoclonal antibodies (MoAbs) including LN1, LN2, MB2, L26, Leu M1, UCHL1, MT1 and L60 was used to evaluate a diverse gro... ...