As to blood, some opposite (diminished or increased) values in all three cell lines may occur. When examining the bone marrow smears, a significant diversity is usually observed both in the extent of myeloid hy
In CML, LSCs display many features akin to haemopoietic stem cells, namely quiescence, self-renewal and the ability to produce mature progeny, this all occurs through intrinsic and extrinsic signals within the specialised microenvironment of the bone marrow (BM) niche. One important avenue of ...
Nineteen patterns with CML have been transplanted in our Bone Marrow Transplantation (BMT) section since 1991, The mean age of these patients was 26.05 (SD = 9.35). Our conditioning regimen for these patients was cyclophosphamide 60mglkg for 2 days and busulfan 4mglkg for 4 consecutive days....
Bone marrow findings in leukemias and lymphomas are discussed in the sections on various leukemias and lymphomas. There are also various scenarios for bone marrow failure, including the following: ▪ In aplastic anemia, trephine biopsy is crucial to document bone marrow hypocellularity. Hematopoie...
(1991) Autologous bone marrow transplantation for CML in which retroviral markers are used to discriminate between relapse which arises from systemic disease remaining after preparative therapy vs relapse due to residual leukemia cells in autologous marrow: A pilot trial. Hum. Gene Ther. 2 , 359–...
The central role of the endothelial microenvironment in orchestrating bone marrow (BM) homeostasis and hematopoietic support has been confirmed at various developmental stages and in adult life. The BM vasculature is crucial in mediating communication be
Abdelhay's team have compared the proteome of bone marrow plasma in CML imatinib (Gleevec) responders and nonresponders. We discuss their findings of dysregulated redox and Wnt signaling in imatinib resistance, illustrating how powerful proteomics may be in the discovery of new therapeutic mechanisms...
High-dose chemotherapy with autologous transplantation of in vivo purged PBSC is a new and interesting therapeutic option for CML patients not eligible for allogeneic transplantation. We investigated the feasibility and toxicity of this approach in 57 patients with Ph-positive CML. For mobilization of ...
The central role of the endothelial microenvironment in orchestrating bone marrow (BM) homeostasis and hematopoietic support has been confirmed at various developmental stages and in adult life. The BM vasculature is crucial in mediating communication be
Malignancies that begin in the bone marrow can be divided into: (i) blood cancers that develop from the blood-forming cells of the marrow [6–8], and (ii) primary bone cancers, commonly known as sarcomas, that form as solid tumors by the bone tissue cells themselves [9,10]. The most...