The formation of the internal skeleton is of major significance in the development of vertebrae. This occurs by endochondral ossification in which bone replaces a cartilage intermediate derived from mesenchymal tissue, and replaces intramembranous bone formation in which undifferentiated mesenchymal tissue ...
Harvard School of Dental Medicine, Harvard University, USAa b s t r a c t a r t i c l e i n f oArticle history:Received 23 December 2014Revised 21 April 2015Accepted 22 April 2015Keywords:Bone developmentEndochondral ossificationIntramembranous ossificationTranscription factorsSomite differentiation...
Intramembranous ossification is the process of bone development from fibrous membranes. It is involved in the formation of the flat bones of the skull, the mandible, and the clavicles. Ossification begins as mesenchymal cells form a template of the future bone. They then differentiate into osteobla...
Embryologically, bone development (osteogenesis, or ossification) occurs in two basic settings. In intramembranous ossification, bones, particularly the frontal and parietal bones of the cranial vault, ossify by apposition on tissue within an embryonic connective tissue membrane. Most bones in the ...
Bone formation can be achieved in two ways: intramembranous ossification (IMO) and endochondral ossification (EO), these mechanisms play important roles in natural bone repair after injury and bone development. In short, IMO can increase the number of Osteoblast-related cells in the inner and outer...
Bone development and bone remodeling are processes primarily governed by osteoblast, osteoclast, and chondrocyte differentiation and activity. Fetal bone development proceeds through two courses, intramembranous ossification (typical in flat bone formation) and endochondral ossification (primarily in long bones...
Flat bones develop by intramembranous ossification. Bone tissue contains hydroxyapatite and various extracellular proteins, producing bone matrix. Two biological mechanisms, determining the strength of bone, are modelling and remodelling. Modelling can change bone shape and size through bone formation by ...
MPs are essential to skeletal development and repair Full size image The condensation of mesenchymal cells is the first event of skeletal development and regeneration, followed by endochondral ossification or intramembranous ossification. The condensed mesenchymal cells are the initial source of MPs. Genera...
There are two types of bone ossification, intramembranous and endochondral. Each of these processes begins with a mesenchymal tissue precursor, but how it transforms into bone differs. Intramembranous ossification directly converts the mesenchymal tissue to bone and forms the flat bones of the skull,...
De Spiegelaere, W.; Cornillie, P.; Casteleyn, C.; Burvenich, C.; Van den Broeck, W. Detection of hypoxia inducible factors and angiogenic growth factors during foetal endochondral and intramembranous ossification.Anat. Histol. Embryol.2010,39, 376–384. [Google Scholar] [CrossRef] ...