The present study examined the effects of alendronate (ALN) on bone matrices formed by intramembranous ossification in the appendicular growing skeleton. ALN was administered to 1-week-old Sprague–Dawley rats at a dose of 0, 35, or 350 µg/kg/week for 4 or 8 weeks. The position of ...
[85], which is characteristic of craniofacial bone derived from intramembranous ossification. The differences in the histological appearance of bone formed by postmigratory CNCC and BMMSCs might be the result of intrinsic differences in embryological origin and functional demands at each skeletal site[...
45Figure 4shows microCT images with greatly increased femoral trabecular bone content in KO mice. In addition to influencing osteoclast function, S1P is also produced by osteoclasts and stimulates bone formation by osteoblasts.44,80Complete genetic rescue of the non-lymphoid lesions, including osteopetr...
Bone - Osteogenesis, Ossification, Intramembranous: Bone is formed in the embryo in two general ways. For most bones the general shape is first laid down as a cartilage model, which is then progressively replaced by bone (endochondral bone formation). A
However, both endochondral and intramembranous bone share similar master regulatory transcription factors and downstream growth factors. Fracture healing mirrors the pathway by which these bones developed embryonically. In contrast, bone formed by distraction osteogenesis does so by intramembranous ossification...
Staining of skeletal preparations from newborn homozygous mutant mice with alcian blue and alizarin red indicated a virtual absence of mineralization in all facial and skull bones formed by intramembranous ossification (Figure 2H), whereas supraoccipital, exoocipital, basioccipital, basisphonoid, and ...
Intramembranous ossification Direct transformation of mesenchymal tissue into bone. Endochondral ossification Bone formation via an intermediate cartilage template. Chondrocytes Cells of mesenchymal origin that produce cartilaginous matrix. Osteoblasts Bone-forming cells of mesenchymal origin that produce extracellular...
Intramembranous ossification beginsin uteroduring fetal development and continues on into adolescence. At birth, the skull and clavicles are not fully ossified nor are the sutures of the skull closed. This allows the skull and shoulders to deform during passage through the birth canal. The last b...
byintramembranous ossification, a process of direct deposition of bone onto a connective tissue network. Bone is deposited by osteoblasts and mobilized byosteoclasts, whereasosteocytesare relatively inactive bone cells found isolated in the bone matrix. Longitudinal growth of long bones occurs at the...
The greater palatine foramen (or canal) perforates the rear corner of the hard palate and is formed as the alveolar process of the maxilla meets the horizontal plate of the palatine. This canal transmits the greater palatine vessels and nerve. c. The two halves of the pterygopalatine canal...