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文档标签: BMS-936564MDX-1338 A fully human anti-CXCR4 antibody induces 系统标签: antibody bms anti induces fully human Anti-CXCR4invitroandinvivopre-clinicalactivity1BMS-936564/MDX-1338:Afullyhumananti-CXCR4antibodyinducesapoptosisinvitroandshowsantitumoractivityinvivoinhematologicmalignancies.MichelleR...
To examine the therapeutic potential of blocking CXCL12-CXCR4 interactions, we studied the effect of BMS-936564, a fully human IgG4 anti-CXCR4 antibody, using an in vitro co-culture model of human bone marrow derived stomal-NKter cells – leukemia cell interaction. Such stromal-NKter cells ...
In addition, we show that MDX-1338 induced apoptosis on a panel of cell lines and propose that antibody-induced apoptosis is one of the mechanisms of tumor growth inhibition.Conclusions: BMS-936564/MDX-1338 is a potent CXCR4 antagonist which is efficacious as monotherapy in tumor-bearing mice ...