C, Castaneda L, Gu H, Wong O, Li H, Berman R, Smith C, Albright CF, Dockens R and Arroyo S (2010) The safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of BMS-708163 in young and elderly subjects. Poster presentation at the International Conference on Alzheimer...
Secondary objectives included single-dose pharmacokinetics in CSF and plasma, safety and tolerability. Methods This was a double-blind, placebo-controlled, randomized, single-dose study. Healthy male subjects were assigned to one of three sequential avagacestat dose panels (50, 200 and 400mg) or ...
The primary objective of this open-label, nonrandomized, single-sequence study was to assess the effects of BMS-708163 on the pharmacokinetics of CYP-isoform specific probes: midazolam (CYP3A4), S-warfarin (CYP2C9), caffeine (CYP1A2), omeprazole (CYP2C19), and dextromethorphan (CYP2D6) in...