Since the primers are designed to probe the α subunit of HGF mRNA (Figure 1A) and a single band (~ 45 kDa) can be detected under non-reducing conditions (Figure 1B, left), the secreted protein might be an isoform of HGF [34]. Secondly, if an autocrine loop is not involved...
A number of mRNAs are known to arise from RNA editing through adenosine deamination in a variety of organisms from Caenorhabditis elegans to humans 9, 10, 11, 12. An important consequence of this reaction is that the sequences of certain proteins present at a given time in an organism are ...
Purple arrow, green arrow and blue arrow indicate the position of three primers (Bmsei-p7, Bmsei-q9 and Bmsei-q8), respectively. Black arrows in isoforms I and III denote premature stop codons. (E) Predicted structures and domains of Bmsei protein and isoforms. Scientific Reports | 5:...
Since the primers are designed to probe the α subunit of HGF mRNA (Figure 1A) and a single band (~ 45 kDa) can be detected under non-reducing conditions (Figure 1B, left), the secreted protein might be an isoform of HGF [34]. Secondly, if an autocrine loop is not involved...
To determine the potential of BMS-986158 to reverse HIV-1 latency, an established HIV-1 latent J-Lat A10.6 cell line, which bears integrated HIV-1 long terminal repeat (LTR)-Tat and green fluorescent protein (GFP) genes, was treated with different concentrations of BMS-986158 (0.8–500 nM...
(S××g−111trm00he−−44Maa−t1t)etrhceamtaluyttaictioefnfiocifeDnc1y81oAn promoted the enzymaticRaaffcintoisve ity BmSUC1 52.32 ± 17.22 0.025 ± 0.0028 aDn1d81Akineti3c2.0p3r±o4.p43erties0.0o21f±B0.m001S4 UC1 2.91 × 10−4 (F6i.5g6u× 1r0e−4 3, Table 3, ...
To determine the potential of BMS-986158 to reverse HIV-1 latency, an established HIV-1 latent J-Lat A10.6 cell line, which bears integrated HIV-1 long terminal repeat (LTR)-Tat and green fluorescent protein (GFP) genes, was treated with different concentrations of BMS-986158 (0.8–500 nM...
BMS-986158 almost completely inhibited BRD2 and BRD4 activity at 10 nM, with 50% inhibitory effect (IC50) values of 1.17 nM and 2.75 nM, respec- tively (Figure 3A,B). JQ1 was used as a control, with IC50 values of 30.18 nM (BRD2) and 62.71 nM (BRD4). Thus, these results imply...