Transcription factors also play a pivotal role in BMP signaling regulation. BMP signaling exerts a growth-suppressive effect in HT-29 through upregulation of RUNX3, which binds with T-cell factor 4 (TCF4) to form a complex with β-catenin. This complex negatively regulates WNT signaling by inh...
deletion of its N-terminal domain (including the RING finger domain required for E3 ubiquitin ligase activity;hiwΔN/ΔN)33, exhibited increased Tkv on the surface of ISCs in homeostatic conditions (Fig.2a, band Supplementary Fig.2b). However, these conditions did not influence downstream DPP s...
Data are displayed as means ± S.D. (**P o0.01, n = 3). (b) MCF-7 cells were induced with 4 ng/ml rhBMP-2 for 24 h, and Smad1/5/8 and p-Smad1/5/8 were detected by western blot (*P o0.05, n = 3). (c) ELISA was performed to detect the expression level of BMP-2...
Monitor file sizes in memory-sensitive environments In environments where memory is limited, such as mobile apps or embedded systems, the large file size of BMP can be a drawback. PNG’s efficient compression makes it a better choice, helping to optimize memory usage without a drop in image ...
was applied to both eyes. Anaesthesia was maintained with ∼2% Isoflurane (Isoflurane-Vet, Merial, UK) in 100% oxygen. Pre- and 2 days post-operative analgesia was given by means of carprofen (Rimadyl™ 4 mg/kg, 50 mg/mL, Zoetis) intra-muscular (IM) injection. Prophylactic antibiotics...
All data are expressed as the means ± standard error (SE). The experiments were performed at least three times to ensure reproducibility. Statistical differences between the two groups were determined using one-way analysis of variance (ANOVA) or Student’s t test. A P value < 0.05 (*)...
Human bone morphogenetic protein ( hBMP ) was extracted and purified from human bone matrix by means of a conbination of differential precipitation, ultr-a... Z Hui - 《Journal of First Military Medical University》 被引量: 48发表: 1988年 Long-term safety and efficacy of human bone morphog...
Statistical analysis. Data were expressed as means ± standard deviation of triplicate measurements with all experiments independently repeated at least three times. Unpaired Student's two-tailed t-tests were used to evaluate statistical differences. Values of p < 0.05 were ...
Statistical Analysis. The results of the quantitative assays were expressed as the means ± standard error of the mean (SEM). A one-way analysis of variance (one-way ANOVA) was used to compare differences in the quan- titative results from the groups at weeks 4 and 12, ...
Application of the composition may be by means of injection at the site, as well as implantation during surgery, or other application which will result in the BMP-11 protein exhibiting the desired effects. Such compositions may find use in protection or repair of neuronal tissue in various ...