BMP8b is the only BMP predominantly expressed in mature brown adipocytes and uniquely sensitizes brown adipocytes to adrenergic input, amplifying their thermogenic response17,18. Its physiological relevance is attested by the reduced thermogenic response and impairment in diet- and cold-induced thermogenesi...
BMP, which stands for Bitmap, is a raster graphics image format that stores pixel data as a series of bits PNG, or Portable Network Graphics, is a raster graphics file format that was developed as a more advanced and flexible alternative to the widely us
Attempts were made to immobilize liposomal BMP-2 onto different biocompatible scaffolds for a sustained, long-term release. Electrospun poly(L-lactic acid) fibers, functionalized with hydroxyapatite (HA) can be a good carrier for BMP-2 loaded liposomes. Adipose tissue-derived MSCs were seeded onto...
Bone is one of the most important organs in the human body. It provides structure, function, and protection for other vital organs; therefore, bone maintenance and homeostasis are critical processes. As humans age, their bone mineral density decreases, w
Introduction:A 3D-printed construct made of orthogonally layered strands of tricalcium phosphate (TCP) and hydroxyapatite has recently become available. The material provides excellent osteoconductivity. We simulated a medium-term experiment in a sheep calvarial model by priming the blocks with BMP-2. ...
the limitation of this drug in the long term is due to its diverse (pleiotropic) effects, including potentially harmful side effect. After their diffusion through the cellular membrane due their lipophilic characteristic, glucocorticoids bind the respective glucocorticoid receptor, activating a downstream ...