The Whited lab showed that blastema cells in regenerating axolotl limbs experience replication stress and that interference with DNA damage response pathways impairs limb regeneration45. Additionally, senescent cells accumulate in regenerating salamander limbs46. Yet, these are efficiently cleared and appear...
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Fig. 2: BMP-dependent transcription is abolished inMZsmad4amutants, while Nodal target gene expression is maintained. aRNA-seq on WT and MZsmad4aembryos performed in triplicate. In the heatmap the color legend shows scaled RLog transformed expression counts for each replicate.bRNA-seq reads fo...
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MSCV-PM-sh-180_1 was obtained from Stephen Elledge lab (Harvard Medical School). BmprIβ construct (MR208067) was purchased from Origene. Plasmid expressing wild-type TGFβRII (pcDNA3.1/His-TGFBR2), and hereafter described as TgfβrII in this manuscript, was provided by Johannes Gebert (U...
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Once the neural tube closes, BMP functions as a morphogen to regulate neural tube patterning and specify the neuronal subtypes in the dorsal neural tube (re- viewed in [12]). Furthermore, BMP signaling regulates neurogenesis and gliogenesis. BMP2 and BMP4 have been shown to promote astrocyte...
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