ExamplePaoletti et al. [27] provide a tutorial of the practical considerations for designing CRM trials; they describe the design, conduct, and analysis of a multicentre phase I trial to find the MTD (defined as the dose with probability of a DLT closest to 20%) of rViscumin in patients ...
this penalization is too high. To remedy this situation, we propose to apply the penalization only on a per-order of regulation basis. Using this modified scheme, the penalization will be 2χα,4+χα,12, which constitutes considerable savings, thereby increasing better prediction ratio (in ter...
We developed a freely available R software package ('dropbead'; including a tutorial), which offers an easy and systematic framework for exploratory data analysis and visualization. ’dropbead’ provides a function for computationally determining the inflection point and hence the number of cells in...
A two hour session on communications skills based on the Calgary-Cambridge model [12] was designed to attempt to remedy this. The communication skills session incorporates basic communication skills theory as well a video demonstration of a fifth-year medical student communicating with a simulated ...
[49,50]. To remedy this we applied double cross-validation (also called double-loop or nested cross-validation) [51] where the dataset was split into totally 25 parts. In each round of inner cross-validation a model was built on 16/25 of the whole dataset and evaluated on 4/25 of ...