南京大学医学院研究团队在探讨羟氯喹对狼疮小鼠骨髓来源抑制性细胞(BM-MDSCs)凋亡的影响及其可能的分子调控机制的相关研究中,为了验证羟氯喹和CD81在BM-MDSCs凋亡中的关系,使用RFect小核酸转染试剂将siRNA转染BM-MDSCs,敲低BM-MDSCs中CD81的表达水平,并评估羟氯喹对CD81表达水平的影响。qRT-PCR和Western blotting的...
Material and Methods Bone marrow cells were harvested and cultured with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-6 (IL-6) for 4days to generate Gr1+ CD11b+ BM-MDSCs.Vascularized heart from BALB/c mice was transplanted into the abdomen of C57BL/6 mice. F...
Our previous study showed that G-CSF might induce the expansion of MDSCs in the BM and peripheral blood (PB) in vivo and higher frequency of MDSCs consisted in G-BM grafts than G-PBSC grafts [15]. Based on these study results, we hypothesized that G-BM grafts lead a better GVHD-...
Our previous study showed that G-CSF might induce the expansion of MDSCs in the BM and peripheral blood (PB) in vivo and higher frequency of MDSCs consisted in G-BM grafts than G-PBSC grafts [15]. Based on these study results, we hypothesized that G- BM grafts lead a better GVHD-...
Granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cells (G-PBSC) has largely replaced unstimulated bone marrow (un-BM) for allografting because of accelerated engraftment, but with a higher morbidity and mortality of graft-versus-host-disease (GVHD). Recent studies sugges...
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人物简介: 高红丽,曾担任山东达民化工股份有限公司等公司高管。 老板履历 图文概览商业履历 任职全景图 投资、任职的关联公司 商业关系图 一图看清商业版图 更新时间:2024-11-16关联企业0 担任法定代表人0 担任股东0 担任高管0 所有任职企业0 作为最终受益人0 所属集团0 历史信息2 曾担任法定代表人 曾担任...
Reversal of the suppressive effect of BM-MDSCs on T-cell proliferation by inhibitors of inducible nitric oxide synthase (iNOS).Júlia, KurkóAndrás, VidaTímea, OcskóBeata, TryniszewskaTibor, A. RauchTibor, T. GlantZoltán, Szekanecz