Purpose To investigate the impact of BM-MDSCs on murine heart transplantation. Material and Methods Bone marrow cells were harvested and cultured with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-6 (IL-6) for 4days to generate Gr1+ CD11b+ BM-MDSCs.Vascularized ...
In ex vivo suppression assays, M-MDSCs, enriched from spleens of LP-BM5 infected mice inhibited both T- and as a novel finding, B-cell responsiveness. For M-MDSC suppression of T-cell proliferation and IFN-gamma production, we previously reported the mechanism to be almost completely iNOS/...
Comparison of suppressive activity of MDSCs with BM-derived IMCs.Parvin, ForghaniWayne, HarrisCynthia, R. GiverAbbas, MirshafieyJacques, GalipeauEdmund, K. Waller
This study provides the basis to investigate the鈥攑otentially beneficial鈥攔ole of expanding MDSC in influencing the risk of GVHD during chimerism induction.doi:10.1038/bmt.2011.207A LuyckxE SchouppeO RutgeertsC LenaertsC KoksS FeveryT Devos...
Phenotype and morphology of myeloid-derived suppressor cell (MDSC)-like cells generated in vitro from murine bone marrow (BM) in comparison with synovial fluid (SF) cells.doi:10.1371/journal.pone.0111815.g001K. JuliaVida ...