Cardiac amyloidosisMachine learningRoutine blood testsMulti-system dysfunction profilePrediction modelCurrent approaches for cardiac amyloidosis (CA) identification are time-consuming, labor-intensive, and present challenges in sensitivity and accuracy, leading to limited treatment efficacy and poor prognosis for...
Ablood testcalledplasmaAβ ratio has, in research studies, been found to have a high performance in detecting brain amyloidosis, and this test is today offered for clinical use in patients with cognitive impairment in the US. However, the "fold change" (difference in plasma Aβ values between...
Data-driven, two-stage machine learning algorithm-based prediction scheme for assessing 1-year and 3-year mortality risk in chronic hemodialysis patients Article Open access 05 December 2023 A machine learning prediction model for Cardiac Amyloidosis using routine blood tests in patients with left ...
Because this test is a side-by-side comparison of the untreated ACT with the heparinase ACT, it also has the advantage of being a rapid test for assessment of a circulating heparin-like substance or for residual heparinization after CPB. With the introduction of ACT monitoring into cardiac ...
acta neuropathol commun (2020) 8:213 https://doi.org/10.1186/s40478-020-01087-1 RESEARCH Open Access Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer's disease Rodrigo Morales1,2*† , Claudia Duran‑Anio...
The reference range for creatinine concentration in the hamster is 0.4–1.0mg/dl (Table 3.6) and is affected by sex and age (Murphy et al., 1984) as well as disease states. Elevatedserum creatininehas been found in hamsters with renalamyloidosisand thenephrotic syndrome(Murphy et al., 1984...
For example, in amyloidosis, amyloid, an abnormal protein passes into (infiltrates) many tissues in the body. If amyloid infiltrates the heart’s walls, they stiffen, and heart failure results. In tropical countries, infiltration of heart muscle by certain parasites (such as in Chagas disease) ...
drugs that are similar toepinephrineandnorepinephrine(such asdopamineordobutamine) or other drugs that make cardiac muscle contract more forcefully (such asmilrinone) are sometimes used for a short time to enhance the pumping function of the heart. These drugs are not useful for long-term treatment...
select article Retrospective Analysis of Autologous Stem Cell Transplantation for AL Amyloidosis: A Study from the Multiple Myeloma Working Group of the Japan Society for Hematopoietic Cell Transplantation Research articleOpen archive Retrospective Analysis of Autologous Stem Cell Transplantation for AL Amyloido...
A different pattern of LGE is described in patients with increased left ventricular mass caused by amyloidosis. Thereby, the gadolinium kinetics seems to reflect the severity of the cardiac amyloid burden (Maceira et al., 2008). Regarding HCM, LGE was reported to be more prevalent in gene-...