Blood:分子分类可改善BCR-ABL1阴性B-ALL成人患者的风险评估 基因组分类改善了B系急性淋巴细胞白血病(B-ALL)儿童患者的风险分配,但对B-ALL成人患者的无优化作用。国际性UKALLXII/ECOG-ACRIN E2993 (#NCT00002514) 试验累计招募了1229位BCR-AB...
Guo J, Wang J, Arlinghaus R: Detection of BCR-ABL pro- teins in blood cells of benign phase chronic myelogenous leukemia patients. Cancer Res 51:3048, 1991Guo JQ, Wang JYJ, Arlinghaus RB: Detection of BCR-ABL proteins in blood cells of benign phase chronic myelogenous leuke- mia ...
also called the Philadelphia chromosome, giving rise to the BCR-ABL1 fusion protein. Current treatment with tyrosine kinase inhibitors is directed against the constitutively active ABL1 domain of the fusion protein, and minimal residual disease (MRD) after therapy is monitored...
BCR-ABL1 p210 testing had been performed using a laboratory-developed quantitative RT-PCR assay. Statistical analysis of the results was performed using an unpaired t test, and P values of <.05 were considered statistically significant. Results Twenty-four patients received a new diagnosis of CML...
To investigate the mechanisms behind the leukemic expansion of BCR/ABL-positive chronic myelogenous leukemia (CML), we examined the cell cycle status of hematopoietic progenitor cells from peripheral blood (PB) and bone marrow (BM) of 37 patients with newly diagnosed BCR/ABL-positive CML. We foun...
Overall, TK fusion proteins other than BCR-ABL in chronic myeloid leukemia (CML) constitute only a relatively small proportion of mutational events in MPN, whereas point mutations in JAK2 (V617F), CALR, MPL, KIT (D816V), ASXL1, TET2, SRSF2, RUNX1, NRAS, KRAS, CBL, IDH1/2, EZH2, ...
Atypical chronic myeloid leukaemia (aCML) A Ph-negative, BCR–ABL1-negative disorder with leucocytosis resulting from an increase in neutrophils and their precursors, the precursors (promyelocyte to metamyelocytes) constituting a least 10% of PB white cellsBasophils < 2% of white cellsMonocytes <...
Myeloproliferative neoplasms (MPN) constitute one of five categories of myeloid malignancies, according to the World Health Organization (WHO) classification system for hematopoietic tumors (Table 1) 1.“BCR-ABL1-negative MPN” is an operational sub-category of MPN that includes polycythemia vera (PV...
Acute Myeloid Leukemia with BCR/ABL Fusion Chimera. Indian J Hematol Blood Transfus 30 (Suppl 1), 280–282 (2014). https://doi.org/10.1007/s12288-014-0359-3 Download citation Received11 December 2013 Accepted17 February 2014 Published07 March 2014 Issue DateSeptember 2014 DOIhttps://doi....
ain colony formation assays using ex vivo peripheral blood and bone marrow samples,inatinib shows inhibition of Bcr -Abl positive colonies from CML patients 在殖民地形成分析用试样使用前体内周边血液和骨髓样品, inatinib Bcr - Abl正面殖民地的展示禁止从CML患者[translate]...