BCR-ABL Fluctuation in Chronic Myeloid Leukemia (CML) Patients with Deep Molecular Response (MR): What is the Meaning of a Big Wave when You Test the Patients in Different Laboratories?Background: Imatinib (IM) is a first choice drug for treatment of chronic myeloid leukemia (CML), with a...
it is unlikely that “cure” ever means the 0 cells that mark as leukemia. Thus, the odds ratio of relapse for a lousy MRD assay is roughly 1; it increases as the test becomes more sensitive but then may return toward 1 as an even more...
Although PSA is not a perfect test and research is required to determine if PSA screening has differential effects in affected populations, it is a cautionary tale. PSA tests apparently measure an important disease signal, and its deployment as a screening assay plays a significant role in ...
Results with the binary outcome yes/no are often nominal. Results from a PCR test that detects a specified mutation, e.g., for BCR-ABL1 gene can be reported with “yes” (with the interpretation “…gene is present”) or “no” (with the meaning the “…gene is not present”), wit...
Its safety profile is derived from its use as monotherapy in extended stage small-cell lung cancer, highlighted by hypertension, hand-foot syndrome, and fatigue [132]. 3.1.4. Saracatinib Saracatinib, also known as AZD0530, is a dual inhibitor of tyrosine kinases c-Src and Bcr-Abl, ...
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