Although genome-wide association studies (GWAS) have successfully linked genetic risk loci to various disorders, identifying underlying cellular biological mechanisms remains challenging due to the complex nature of common diseases. We established a framework using human peripheral blood cells, physical, che...
Transmission of neurodegenerative disorders through blood transfusion: a cohort study. Ann Intern Med. 2016;165(5):316-324. doi:10.7326/M15-2421PubMedGoogle ScholarCrossref 20. Edgren G, Hjalgrim H, Rostgaard K, et al; NHLBI Recipient Epidemiology and Donor Evaluation Study ...
Comorbidities were defined as per the Implementation of the International Statistical Classification of Disease and Related Health Problems, 10th Revision (ICD-10) coding systems20. APS III21, the Modified Logistic Organ Dysfunction System (MLODS)22, SOFA23, the Oxford Acute Severity of Illness ...
HBIGDA stipulates that a patient must meet the diagnostic criteria for gender identity disorders as defined by either the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) or the International Classification of Diseases–10 (ICD-10). ...
(icd-10-cm d10-d49) were not considered. the main outcome of the study was defined as a first diagnosis of cancer after the date of recruitment or a cancer-related death. similarly, secondary outcomes of the study were considered for the most common cancer types: breast, colon, lung, ...
Most studies diagnosed dementia using Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (DSM-IV) criteria, although some used Diagnostic and Statistical Manual of Mental Disorders (Third Edition Revised) (DSM III-R) criteria (eTable 8 in Supplement 1). Dementia onset was ...
F.Gary Cunningham, in Chesley's Hypertensive Disorders in Pregnancy (Fourth Edition), 2015 Venous System in Normal Pregnancy Mean Circulatory Filling Pressure Venous return to the right heart maintains filling pressure, permitting adaptation to changing cardiac output requirements. A prerequisite for such...
(ICD)-9/10 chapters, that might share causes and similar associations with blood group, i.e., circulatory, endocrine, respiratory, neoplasms, digestive, neurological, musculoskeletal, gynecologic and obstetric, hematopoietic, dermatologic, genitourinary, mental health, infectious diseases, sense organs, ...
Malignant blood disorders depend on heritable susceptibility genes and occur in familial aggregations. We suggest a model of transgenerational segregation of the susceptibility genes based on the study of malignant blood disorders in Norwegian and Danish families with unrelated parents, and in the inbred...
True negatives were common benign missense variants were obtained from the gnomAD database (in this database there are no known severe Mendelian disorders and as such it is assumed that highly penetrant disease-causing missense variants will be rare in this database (allele frequency < 1%)), ...