Although genome-wide association studies (GWAS) have successfully linked genetic risk loci to various disorders, identifying underlying cellular biological mechanisms remains challenging due to the complex nature of common diseases. We established a framework using human peripheral blood cells, physical, che...
Transmission of neurodegenerative disorders through blood transfusion: a cohort study. Ann Intern Med. 2016;165(5):316-324. doi:10.7326/M15-2421PubMedGoogle ScholarCrossref 20. Edgren G, Hjalgrim H, Rostgaard K, et al; NHLBI Recipient Epidemiology and Donor Evaluation Study ...
code for malignant cancer (icd-10 chapter c) [37]. benign neoplasms (icd-10-cm d10-d49) were not considered. the main outcome of the study was defined as a first diagnosis of cancer after the date of recruitment or a cancer-related death. similarly, secondary outcomes of the study ...
HBIGDA stipulates that a patient must meet the diagnostic criteria for gender identity disorders as defined by either the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) or the International Classification of Diseases–10 (ICD-10). ...
(including the National Heart, Lung, and Blood Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute on Aging, and the National Institute of Neurological Disorders and Stroke) under contracts HHSN268200900040C, HHSN268200900046C, HHSN268200900047C, HHSN...
True negatives were common benign missense variants were obtained from the gnomAD database (in this database there are no known severe Mendelian disorders and as such it is assumed that highly penetrant disease-causing missense variants will be rare in this database (allele frequency < 1%)), ...
(IHD) coded as ICD-10 I20-I25. Each case was matched to one control free of CHD, cancer, or cerebrovascular diseases throughout follow-up. Cases and controls were one-to-one matched by birth year (within 3 years), age at baseline (within 3 years), sex, study area, and fasting ...
942 variants in the FinnGen release 10 results (https://www.finngen.fi/en/access_results). Disease traits were defined in terms of “Phenotype Description” in the original FinnGen data, and were organized into ICD code format to facilitate correspondence to specific diseases in different ...
The positive predictive value of ICD-9 code 428 as a primary diagnosis has been reported to be 94.3% using the Framingham criteria and 88.6% using criteria previously validated with pulmonary capillary wedge pressure [62]. Since heart failure is a complex and progressive syndrome whose recognition...
disorders. Integration of MR data at systems-level into networks and whole-genome gene expression obtained from control and diseased tissues provides a solid framework to explore, with a holistic approach, the pathways involved in different traits and disorders34,35. Herein, we leveraged large-scale...