a class I and / or class II histone deacetylase inhibitor, non taxane replication It is a hitherto or proteasome inhibitor.The combination is beneficial in the sense that the cancer cells are sensitized against the drug, while protecting the normal cells from the toxicity induced by the drug.ヴ...
Rowley was also among the first to note that most of the cancerous cells in a group of patients with a different type of leukemia involving lymphocyte-like cells had common recurring chromosomal breakage patterns, but that these translocations were different from that seen in CML. It then ...
An updated strategy combining pediatric-based chemotherapy with risk-oriented allogeneic hematopoietic cell transplantation (HCT) was evaluated in Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph− ALL) and compared with a published control series. Following induction–consolidation chemotherapy...
While some of the genes harboring germline variants with a significant burden in myeloid malignancy cases had previously been implicated in blood cancer predisposition, such as CHEK2,24 several were unknown. Among this group, CTR9 was of particular interest because germline variants in the gene had...
Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal with the detection of mutations. The analysis of cfDNA is often discussed in the context of the noninvas...
,... - 《Clinical Cancer Research》 被引量: 65发表: 2013年 Plerixafor: A Peripheral Blood Stem Cell Mobilizer Autologous hematopoietic stem cell (HSC) transplantation is a treatment strategy for restoring normal hematopoietic function in patients with select hemato... MR Kessans,ML Gatesman,DR ...
An ideal strategy is to generate autologous RBCs using iPSCs, but the process is not feasible in clinical settings owing to the long time required for supplying the manufactured blood for transfusion and high cost of production. Irrespective of the number of blood donors, maintaining an all-...
Myeloma is a cancer of the immune cells produced in the bone marrow. The disease puts patients at greater risk of severe COVID-19 infection and there were concerns that it could also cause them to have less protection in response to any vaccine. ...
Anderson International Journal of Hematology (2016) Strategy for enhancing the therapeutic efficacy of histone deacetylase inhibitor dacinostat: the novel paradigm to tackle monotonous cancer chemoresistance Shabir Ahmad Ganai Archives of Pharmacal Research (2015)...
The most representative molecules are the P-glycoproteins, the multidrug resistance proteins, and the breast cancer resistance proteins. Some isoforms of the multidrug resistance proteins can also be located in the abluminal membrane of the endothelium, which explains the bidirectional flow that some ...