Tumor suppressor geneLymphomaB lymphocyte-induced maturation protein (Blimp-1) is a transcriptional factor, which controls the terminal differentiation of mature B cells to plasma cells. Blimp-1 is also called positive regulatory domain I-binding factor-1 (PRDI-BF1) or PR (PRDI-BF1-RIZ) ...
6. Chihara, N., Madi, A., Kondo, T., Zhang, H., Acharya, N., Singer, M., et al. (2018). Induction and transcriptional regulation of the co-inhibitory gene module in T cells. Nature 558 (7710), 454–459.
Gene Name: PRDM1 Protein Name: PR domain zinc finger protein 1 Human Gene Id: 639 Swiss-Prot: O75626 Formulation: Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol. Source: Monoclonal, Mouse Dilution: WB: 1:500-1:2000 ELISA: 1:10000 PurIF:ication: Affinity purIF:icati...
说明书 实验方案 技术支持 货号14-5963-80 View price in cart 25 µg100 µg 下单后预计有货时间 21-Mar-2025 查看价格 批量或定制请求 抗体检测数据 (3) 已发表图片 (28) 高级验证 (1) Application Created with Sketch. 图:1/32 Blimp-1 Antibody (14-5963-80) in IHC (P) ...
蛋白别名:B-lymphocyte-induced maturation protein 1; Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP 1; BLIMP-1; MGC118922; MGC118923; MGC118924; MGC118925; OTTHUMP00000016918; OTTHUMP00000202173; Positive regulato...
terminal differentiation of B lymphocytes and monocyte/macrophages. Blimp-1 is expressed in, and may be required for terminally differentiated epithelial cells, retinal neurons and other lineage cells. It has also been implicated in the repression of beta-interferon (IFN-beta) and c-myc gene ...
The researchers further traced this observation to a gene called Prdm1 encoding the proteinBLIMP-1, increased expression of which leads to differentiation and proliferation of plasma cells in B cell immune response (Figure 2). Kurosaki, ERKs induce expression of the transcriptional repressorBlimp-1and...
Identification and characterization of a novel repressor of beta-interferon gene expression[J]. Genes Dev, 1991,5(5):868-879. DOI: 10.1101/gad.5.5.868 . 返回引文位置Google Scholar 百度学术 万方数据 [2] Telerman SB , Rognoni E , Sequeira I ,et al. Dermal Blimp1 cts ownstream of pi...
et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 17, 51–62 (2002). Article CAS Google Scholar Sciammas, R. & Davis, M.M. Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. ...
BLIMP-1 silences IFNi -gene expression by binding specifically to PRDI of the IFNi gene promoter. It is continuously expressed in all Plasma cells, but is not detected in early bone marrow B-cells, memory B-cells in spleen and most germinal center B-cells. In myeloma cells, PRDI-BF1...