446 The PRDM1/ BLIMP1 gene encodes a zinc finger transcriptional repressor that is expressed in a subset of germinal center (GC) B cells and in all plasma cells, and is required for terminal B cell differentiation. The BLIMP1 locus is biallelically inactivated by structural alterations in ...
PRDM1 (PR domain 1) 这个基因编码一种蛋白质,作为β-干扰素基因表达的抑制剂。该蛋白与β-干扰素基因启动子的prdi(阳性调节域i元件)特异性结合。这种基因的转录随着病毒的诱导而增加。已经报道了两种编码不同亚型的选择性剪接转录变体。 This gene encodes a protein that acts as a repressor of beta-...
This is the first report on a novel EBF1 function in immature B cells as a powerful repressor of Blimp-1 gene expression.doi:10.1016/j.bbrc.2012.05.099Hidehiko KikuchiMasami NakayamaYasunari TakamiFutoshi KuribayashiTatsuo NakayamaElsevier Inc.Biochem Biophys Res Commun...
The B lymphocyte-induced maturation protein-1 (Blimp-1) is a transcriptional repressor involved in B cell terminal differentiation. Recent studies suggest that it also plays roles in the differentiation of myeloid and T cells. Using reporter gene analysis, we found that the mouse Blimp-1 promoter...
The researchers further traced this observation to a gene called Prdm1 encoding the proteinBLIMP-1, increased expression of which leads to differentiation and proliferation of plasma cells in B cell immune response (Figure 2). Kurosaki, ERKs induce expression of the transcriptional repressorBlimp-1and...
terminal differentiation of B lymphocytes and monocyte/macrophages. Blimp-1 is expressed in, and may be required for terminally differentiated epithelial cells, retinal neurons and other lineage cells. It has also been implicated in the repression of beta-interferon (IFN-beta) and c-myc gene ...
et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 17, 51–62 (2002). Article CAS Google Scholar Sciammas, R. & Davis, M.M. Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. ...
This provided 254 differentially expressed genes with P < 0.01 (false dis- covery rate was also 0.01) and gene pattern software revealed that Blimp1 mutant and wild-type animals grouped into two distinct clusters (Fig. 5a). This indicates a clear difference in expression pat- terns ...
¥2080.00元/format:100ul 目录号:IMB0316 库存:现货 规格 产品信息 Catalog No. :IMB0316 Reactivity:Human;Mouse Applications:WB; ELISA Gene Name:PRDM1 Protein Name:PR domain zinc finger protein 1 Human Gene Id:639 Swiss-Prot:O75626
asakeyregulatorofBcelldevelopmentandT- celldifferentiationandasasuppressorofBcelllymphoma.Intheembryonicdevelopmentofmiceandother animalstherolesofBlimp1proteininthedevelopmentofprimitivestemcells,andintheformationofmuscle tissuehavebeenpreliminaryunderstood. Keywords:Blimp1;Primitivestemcells;Tumorsuppressorgene;...