由于BKS-db/db小鼠是不育的,所以通常是用BKS-db/m作为父母代去繁育子代,通常用这种方法繁育BKS-db/db时需要大量饲养BKS-db/m以满足实验需求。BKS-db/m的子代共有三种,理论上,1/4是黑色肥胖小鼠,为BKS-db/db;1/2是黑色瘦小鼠,为BKS-db/m,可用于扩繁或作为对照组;1/4为灰色瘦小鼠,为BKS-m/m,可用于...
BKS db小鼠视网膜微血管内皮细胞分离自糖尿病自发突变纯合子小鼠视网膜微血管(Lepr/db),表现为病态肥胖、慢性高血糖、胰岛β细胞萎缩和低血供。BKS db小鼠视网膜微血管内皮细胞在T25组织培养瓶中培养,预先包覆明胶溶液2 min,在AcceGen完全培养基中培养3-7天。在运输之前,第3代的细胞从培养瓶中分离出来,立即冷冻保存...
这些小鼠不仅继承了BKS-db小鼠的肥胖和严重糖尿病特征,还展现出了系统性高血压、更显著的蛋白尿以及肾脏组织的严重病变,从而为临床中重度糖尿病肾病患者的症状提供了模拟,成为DN药物非临床评价的理想模型。随后,集萃药康进一步利用恩格列净(Empagliflozin,一种SGTL2抑制剂)、赖诺普利(Lisinopril,ACE抑制剂)以及S...
BKS-DB miceSmall intestinal floraDGGEThe huge microbial communities play an important role in human physiology. More and more data shows that the intestinal flora, especially small intestinal flora, is closely related to metabolic disease, such as obesity and diabetes. In...
“Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.” Cell 84.3 (1996): 491-495. 2.Yoon, Ji-Won, et al. “Genetic control of organ-reactive autoantibody production in mice by obesity (ob) diabetes (db) ...
从糖尿病自发性突变(Lepr/db)纯合子小鼠肝脏分离出肝窦内皮细胞,表现为病理性肥胖、慢性高血糖、胰腺细胞萎缩和降血脂症。BKS db小鼠肝窦内皮细胞培养于T25组织培养瓶中,预先包覆以明胶为基础的溶液,培养2 min,在AcceGen’s culture Complete Growth Medium中培养,一般扩增培养3-7天。在运输之前,第3代的细胞从培...
Mesenchymal stem cellsConditioned mediumDeferoxamineAD-MSC-conditioned medium administration improves thermal and mechanical sensitivity and restores intraepidermal nerve fiber density in diabetic mice. , Hargreaves plantar test ( ) and Von Frey test ( ) showing the withdrawal latency to thermal stimulus ...
2 型糖尿病 BKS-DB 小鼠的小肠菌 群结构差异性分析[J]. 生命科学研究(WEI Ting, HU Fang, ZHANG Hong-lin, et al. Analysis of microbial flora from the small bowel of BKS-DB2 mice[J]. Life Science Research), 2012, 16(6): 483-488.型糖尿病BKS-DB小鼠的小肠菌群结构差异性分析[J]. 韦婷,...
Composition of STAP-2; Induction of STAP-2 in mice liver in response to lipopolysaccharide; Regulatory role of STAP-2 in the acute-phase response in systemic inflammation.MinoguchiMayuShigeruAkiDaisukeJooAkikoYamamotoTetsuyaYumiokaEBSCO_AspJournal of Biological Chemistry...
In addition, thymocytes from STAP-2/BKS-deficient mice showed the enhanced interleukin-2-dependent cell growth. Taken together, STAP-2/BKS is an additional modulator of STAT5-mediated signaling.SekineDepartmentYuichiDepartmentYamamotoDepartmentTetsuya...