从糖尿病自发性突变(Lepr/db)纯合子小鼠肝脏分离出肝窦内皮细胞,表现为病理性肥胖、慢性高血糖、胰腺细胞萎缩和降血脂症。BKS db小鼠肝窦内皮细胞培养于T25组织培养瓶中,预先包覆以明胶为基础的溶液,培养2 min,在AcceGen’s culture Complete Growth Medium中培养,一般扩增培养3-7天。在运输之前,第3代的细胞从培...
BKS db小鼠脾内皮细胞是从糖尿病自然突变纯合子小鼠脾脏中分离出来的,表现为病态肥胖、慢性高血糖、胰腺β细胞萎缩和低血供。BKS db小鼠脾内皮细胞培养于T25组织培养瓶中,预先包覆明胶溶液2 min,在AcceGen特殊完全培养基中培养3-7天。在运输之前,第3代的细胞从细胞瓶中分离出来,立即冷冻保存在小瓶中。每毫升每瓶...
由于BKS-db/db小鼠是不育的,所以通常是用BKS-db/m作为父母代去繁育子代,通常用这种方法繁育BKS-db/db时需要大量饲养BKS-db/m以满足实验需求。BKS-db/m的子代共有三种,理论上,1/4是黑色肥胖小鼠,为BKS-db/db;1/2是黑色瘦小鼠,为BKS-db/m,可用于扩繁或作为对照组;1/4为灰色瘦小鼠,为BKS-m/m,可用于...
This revealed that the normal mice have larger small intestinal flora than type 2 diabetes mice, while the dominant species and relative abundance were similar . The result of sequencing illustrated that Lactobacillus was in small intestine of normal control mice, but BK...
因此，集萃药康的BKS-db-eNOS KO小鼠模型对于糖肾疾病新药的非临床评价而言，无疑是一个理想的选择。关于集萃药康 江苏集萃药康生物科技股份有限公司，成立于2017年，是一家集实验动物小鼠模型的研发、生产、销售及技术服务为一体的高新技术企业。作为亚洲小鼠突变和资源联盟的重要成员，以及科技部国家遗传工程小鼠资源...
“Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.” Cell 84.3 (1996): 491-495. 2.Yoon, Ji-Won, et al. “Genetic control of organ-reactive autoantibody production in mice by obesity (ob) diabetes (db) ...
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Effects of GW002, a novel recombinant human glucagon-like peptide-1 (GLP-1) analog fusion protein, on CHO recombinant cells and BKS-db mice GLP-1-based strategies have many advantages in treatment of type 2 diabetes mellitus (T2DM), but native GLP-1 has a short half-life in the circulat...
Male db/+ weighed more and had higher blood glucose and corticosterone relative to BL6, but not BKS mice. Also, male db/+ lacked social interaction preference, explored arenas less, and buried more marbles than BL6, but not BKS males. Male and female db/+ were more dominant and made ...
In addition, thymocytes from STAP-2/BKS-deficient mice showed the enhanced interleukin-2-dependent cell growth. Taken together, STAP-2/BKS is an additional modulator of STAT5-mediated signaling.Journal of Biological Chemistry