2024年1月18日,以色列Weizmann科学研究所的研究人员在Cell期刊发表了题为:Bispecific dendritic-T cell engager potentiates anti-tumor immunity的研究文章。 1.背景 使用抗PD-1(aPD-1)单克隆抗体的免疫检查点抑制治疗是一种有前景的癌症免疫治疗方法。然而,它对肿瘤免疫的影响范围较窄,因为大多数患者对该治疗没有反...
在这一发现的基础上,研究团队开发了一种双特异性树突状细胞-T细胞接合剂(Bispecific DC-T Cell Engager,BiCE)双抗,促进PD-1+T细胞和cDC1之间物理相互作用,该双抗的两个抗体臂分别连接两种不同细胞,一个与T细胞(CD8)结合,靶向PD-1,另一个树突状细胞(cDC1)结合,靶向CLEC9A。 在创造了这种BiCE双抗后,研究团队...
单臂双抗(Single-arm BsAb):一种比较简单的结构,有两个不同的抗原结合部位。 双特异性T细胞连接抗体(BiTE,Bispecific T-cell Engager):一种特定类型的双抗,一端结合肿瘤细胞,另一端结合T细胞,促进免疫细胞直接攻击肿瘤细胞。 2. 作用机制: 双抗可以通过将免疫细胞(如T细胞或自然杀伤细胞)与肿瘤细胞或其他靶细胞...
Bispecific T-cell engager (BiTE) immunotherapy is a promising therapy for cancer treatment. However, the high cost and short life-time in vivo of the BiTE limit its wide clinical application. Here, we built for the first time a gene delivery system based on MIL-88A metal organic framework ...
求翻译:Bispecific T cell-engager是什么意思?待解决 悬赏分:1 - 离问题结束还有 Bispecific T cell-engager问题补充:匿名 2013-05-23 12:21:38 双特异性T细胞接合 匿名 2013-05-23 12:23:18 (Bispecific T细胞允诺 匿名 2013-05-23 12:24:58 Bispecific T隐含对参与 匿名 2013-05-23 12:26...
AMG 420 (Amgen) is a bispecific T-cell engager that targets theB-cell maturation antigenon multiple myeloma cells and CD3 on T cells. “In this first-in-human study, AMG 420 — a short half-life bispecific T-cell engager m...
Harnessing the power of immune cells, especially T cells, to enhance anti-tumor activities has become a promising strategy in clinical management of hematologic malignancies. The emerging bispecific antibodies (BsAbs), which recruit T cells to tumor cells, exemplified by bispecific T cell engagers (...
Targeting CD19 with blinatumomab, a CD19/CD3 bispecific antibody construct (BiTE), or with chimeric antigen receptor T cells (CAR-T) has shown great promise for treating certain CD19-positive hematological malignancies. In contrast, solid tumors with heterogeneous expression of the tumor-associated ...
Explore BPS Bioscience’s services for bispecific antibodies and BiTEs. Discover our solutions for developing and optimizing bispecific T-cell engager therapies.
Bispecific T cell engager therapy for refractory rheumatoid arthritis 双特异性T细胞接合剂治疗难治性类风湿关节炎 相关领域 Blinatumoab公司 类风湿性关节炎 医学 B细胞 T细胞 免疫学 CD19 抗体 免疫系统 网址 https://doi.org/10.1038/s41591-024-02964-1 ...