Bispecific T cell Engagers 专利名称：Bispecific T cell Engagers 发明人：Margaret Karow,Richard Yau,Jackie Sheng 申请号：US17164699 申请日：20210201 公开号：US20210246222A1 公开日：20210812 专利内容由知识产权出版社提供 专利附图：摘要：Provided are bispecific T Cell Engagers. More specifically, the ...
Harnessing the power of immune cells, especially T cells, to enhance anti-tumor activities has become a promising strategy in clinical management of hematologic malignancies. The emerging bispecific antibodies (BsAbs), which recruit T cells to tumor cells, exemplified by bispecific T cell engagers (...
During a Targeted Oncology™ Case-Based Roundtable™ event, Medhi H. Hamadani, MD, discussed the bispecific T-cell engagers epcoritamab and glofitamab and how they fit into the treatment algorithm for patients with diffuse large B-cell lymphoma. This is the second of 2 articles based on...
T cell engaging bispecific antibodies that redirect the cytotoxic activity of T lymphocytes to tumor cells have demonstrated preclinical and clinical success in TNBC. Triple negative breast cancer (TNBC), an aggressive breast cancer subtype lacking estrogen receptor (ER), progesterone receptor, and ...
Thomas G. Martin, MD, discusses the safety profile of bispecific T-cell engagers in multiple myeloma.
Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that redirect T cells to tumor surface antigens. While efficacious against certain hematological malignancies, limited bioavailability and severe toxicities have so far hampered broader clinical application, especially against so...
Bispecific T Cell Engagers: An Emerging Therapy for Management of Hematologic Malignancies. J. Hematol. Oncol. 2021, 14, 75. [Google Scholar] [CrossRef] Wolf, E.; Hofmeister, R.; Kufer, P.; Schlereth, B.; Baeuerle, P.A. BiTEs: Bispecific Antibody Constructs with Unique Anti-Tumor ...
bispecific T-cell engagers have proven very potent in eliciting cytotoxic T-lymphocyte-mediated killing. We have tested five anti-IgE Fc antibodies, recognizing different epitopes on the membrane-expressed IgE, for the ability to elicit specific T-cell activation when expressed as single-chain Fv ...