Interference with Lab Tests: High doses of biotin can interfere with certain laboratory tests, including those measuring hormone levels and thyroid function. This interference may result in inaccurate test results, leading to misdiagnosis or inappropriate medical management. Allergic Reactions: Some individ...
Most of the published research on biotin interference covers hormone tests, such asparathyroid hormone (PTH),thyroid stimulating hormone (TSH),T4andT3tests, as well as tests for troponin. However, because biotin is used in so many immunoassays, scientists say it could interfere with many others....
Dietary biotin intake does not typically result in blood biotin concentrations that exceed interference thresholds for in vitro diagnostic tests. However, recent trends of high-dose biotin supplements and clinical trials of very high biotin doses for patients with multiple sclerosis have increased ...
Interference with lab tests Biotin supplements can interfere with specific lab tests, such asthyroidfunction tests, and may cause inaccurate results. Interaction with medication Biotin supplements may interact with certain medications, such as anticonvulsants and antibiotics, and may affect their efficacy....
concentrations of biotin can have a half-life of up to 18.8 h [7].The manufacturers of biotin-streptavidin immunoassays caution interference from elevated blood biotin levels [8], and the US Food and Drug Administration has issued safety warnings about biotin interference in laboratory tests [9]...
20 The time required for patients to stop taking supplements with biotin to avoid assay interference appears to be variable and may depend on the patient population, time of blood collection relative to the last biotin dose, biotin dose, chronicity of biotin exposure, and half-life of free ...
[7]OstrowskaM, Bartoszewicz Z, Bednarczuk T, Walczak K, Zgliczynski W,Glinicki P.The effect of biotin interference on the results of blood hormoneassays. Endokrynol Pol. 2019;70(1):102–121. [8]BrinkmannU, Georges G, Grote M, Hoffmann E. Anti-biotin antibodies andmethods of use...
Patients can continue to take biotin except stopping it temporarily before thyroid blood tests. Conclusion: Biotin interference mimics the laboratory changes in thyrotoxicosis. Prompt recognition of biotin interference requires a high index of suspicion. History of medicine intake including ...