What is the translation process? Understand the process of translation. Learn what happens during the initiation, elongation, and termination phase...
The endoplasmic reticulum (ER) coordinates mRNA translation and processing of secreted and endomembrane proteins. ER-associated degradation (ERAD) prevents the accumulation of misfolded proteins in the ER, but the physiological regulation of this process remains poorly characterized. Here, in a genetic ...
10a–c). We first tested whether 3′ UTR splicing regulated CTNNB1 expression at the transcript or protein level by inhibiting transcription or translation following the overexpression of HA-tagged CTNNB1 variants. The transcript and protein expression of both 3′ FL and 3′ SP variants were ...
Diagram and describe steps of meiosis starting with six chromosomes. Cell Division - Mitosis [Homework Assignment or all Student Materials] Diagram and describe steps of mitosis starting with six chromosomes. CRISPR [Radiolab Homework Assignment] Episode explores CRISPR, a cutting-edge method of gen...
Clearly, Naegleria is an organism uniquely positioned to reveal new insights into both crawling and swimming motility. A completely sequenced genome and publicly available transcriptional profiling of differentiation provide first steps toward harnessing this potential [51,74]. The greatest roadblock remains...
While it is evident that non-canonical Hoogsteen-paired G-quadruplex (rG4) structures somehow contribute to the regulation of translation initiation, the nature and extent of human mRNAs that are regulated by rG4s is not known. Here, we provide new insights into a mechanism by which rG4 ...
This analysis revealed that the expression of all nuclear genes that encode enzymes that are known or predicted to function at each of the individual steps in the CrtBS pathway are highly correlated withPSY(Figure1). In addition,PSYis also highly co-expressed with many isoprenoid-related biosynth...
Three protein isoforms of perilipin have been described that arise from the translation of alternatively spliced mRNA (50, 58). Perilipin A is the largest protein (517 amino acids in mice) and the most abundant protein on adipocyte lipid droplets (4, 50); perilipin B, a less abundant protein...
in the database whose annotations refer to children of the GO terms listed here, after first removing certain GO terms (translation, GO:0006350; transcription, GO:0006412; and cellular metabolic process, GO:0044237) that appear across different categories, and hence would have biased the analysis...
(see the main text).bExternal validation, for which SIAMCAT offers analysis workflows, can expose these issues. The individual steps in the workflow diagram correspond to SIAMCAT functions for fitting a machine learning model and applying it to an external dataset to assess its external validation...